摘要
支气管哮喘(简称哮喘)和慢性阻塞性肺疾病(COPD)均是常见的慢性气道炎症性疾病,气流受限是二者共同发病机制,两者在气道炎症等方面有一定的重叠和交叉,但在病史、发病年齡、肺功能及预后等方面存在一定差异。2014年全球支气管哮喘防治创议(The Global Initiative for Asthma,GINA)和2015年慢性阻塞性肺疾病全球倡议(Global Initiative for Chronic Obstructive Lung Disease,GOLD)指南首次确定了哮喘和COPD合并症的术语,即哮喘-慢性阻塞性肺疾病重叠综合征(asthma-COPD overlap syndrome,ACOS),定义其是以持续性气流受限为特征且同时具有哮喘相关特征和COPD相关特征。据国内外流行病学研究,近年来ACOS在慢性病人群(特别是老年人)中发病率呈上升趋势,本文将对哮喘-慢性阻塞性肺疾病重叠综合征的发病机制进展进行综述。
Bronchial asthma （ asthma） and chronic obstructive pulmonary disease （ COpD） are common chronic airway inflam-mation diseases with the airflow limitation as their common pathogenesis. There are some overlaps in airway inflammation between the two diseases. But there are some differences between these two in the aspects of medical history, age of onset, lung function and prog-nosis. The Global Initiative for Asthma （ GINA） in 2014 and the Global Initiative for Chronic Obstructive Lung Disease （ GOLD） in 2015 compiled the term of the combination of asthma and COpD for the first time—asthma-COpD overlap syndrome （ ACOS ） —, which was based on the definition of persistent airflow limitation combined with asthma related features and COpD related features. Ac-cording to the epidemiological studies at home and abroad in recent years, the incidence of ACOS has an upward trend in patients with chronic diseases （ especially the aged） . This paper will review the pathogenesis progress of ACOS.
作者
廉洁
潘殿柱
LIAN Jie pAN Dianzhu(Department of Respiratory Medicine, the First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001 China)
出处
《辽宁医学院学报》
CAS
2016年第5期107-109,共3页
Journal of Liaoning Medical University (LNMU) Bimonthly
关键词
支气管哮喘-慢性阻塞性肺病重叠综合症
支气管哮喘
慢阻肺
发病机制
Chronic obstructive pulmonary disease （COPD）
bronchial asthma
Chronic obstructive pulmonary disease
patho-genesis
