摘要
目的探讨盐酸戊乙奎醚预处理对肺叶切除术患者全身炎症反应的影响。方法选择行择期肺叶切除术患者120例,随机分为2组（n=60）：观察组于麻醉诱导前10 min静脉注射盐酸戊乙奎醚0.05 mg/kg,对照组于相同时间段注射等容量生理盐水。分别于药物干预前（T0）、单肺通气即刻（T1）、单肺通气60 min时（T2）、单肺通气结束即刻（T3）、术毕（T4）和术后24 h（T5）时抽取两组患者静脉血以检测血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6和8（IL-6、IL-8）的水平。结果与对照组相比较,观察组患者T2-T5时相血清TNF-α、IL-6和IL-8水平均降低（P〈0.05）。结论结论盐酸戊乙奎醚预处理可减轻肺叶切除术患者全身炎症反应。
Objective To explore the effect of penehyclidine hydrochloride preconditioning on inflammatory response in patients undergoing lobectomy. Methods One hundred and twenty adult patients undergoing lobectomy were randomly divided into two groups（ n = 60 each）. Adult patients were injected intravenously with penehyclidine hydrochloride at a dose of 0. 05 mg/kg or with equivalent normal saline 10 min before anesthesia induction in test group and control group.Venous blood was extracted to detect the levels of tumor necrosis factor-alpha（ TNF-alpha）,interleukin-6 and 8（ IL-6,IL-8） in serum before drug intervention（ T0）,immediately when single lung ventilation（ T1）,60 min after single lung ventilation（ T2）,immediately when single lung ventilation end（ T3）,immediately when surgery end（ T4）and 24 h after surgery（ T5）,respectively. Results Compared to control group,the levels of inflammatory factors in serum were all lower（ P〈 0. 05） in test group. Conclusion Penehyclidine hydrochloride preconditioning can alleviate inflammatory response in patients undergoing lobectomy.
出处
《医药论坛杂志》
2016年第9期7-8,共2页
Journal of Medical Forum
基金
河南省高校重点科研项目(NO.15A320076)
关键词
戊乙奎醚
炎症反应
单肺通气
肺叶切除术
Penehyclidine
Inflammatory response
Single lung ventilation
Lung resection
