摘要
目的探讨腹横肌平面阻滞对腹腔镜下行结肠癌手术患者外周血Th1/Th2比值的影响。方法选取择期行腹腔镜下结肠癌根治术患者44例,随机分为对照组(常规全麻复合生理盐水腹横肌平面阻滞完成手术)和腹横肌平面阻滞组(常规全麻复合0.5%盐酸罗哌卡因15 m L双侧腹横肌平面阻滞完成手术)。采集麻醉诱导后10 min、手术结束和术后24 h患者的动脉血,应用免疫酶联试验试剂盒检测血浆干扰素-γ和白细胞介素4水平,并以干扰素-γ和白细胞介素4比值计算Th1/Th2比值。结果对照组Th1/Th2在手术结束及术后24 h较基础值有显著降低;术后24 h,对照组Th1/Th2比值较腹横肌平面阻滞组显著降低(P<0.05)。结论腹横肌平面阻滞能够增加腹腔镜下行结肠癌手术患者外周血Th1/Th2比值。
Objective To investigate the effects oftransversus abdominis plane（TAP） block on patients＇ Th1/rh2 ratio. Methods A total of 44 patients were enrolled. All patients requiring left or right hemi colectomy were randomly assigned to two groups ： the general anesthesia control group with saline TAP block （control group）, and the general anesthesia with 0.5% ropivacaine 15 mL TAP block （TAPB group）. Plasma sam- pies were. obtained at three time points ： 10 min after anesthesia induction, end of surgery and postoperative 24 h. The inflammatory cytokines （in- terleukin-4, IL-4 ; interferon-gaumla, IFN-γ） concentrations in each of the two groups were detected by ELISA, and Th1/Th2 intio was calculated with the ratio of IFN-γ and IL-4. Results The Th1/Th2 ratio in control group was decreased at the end of surgery and continuously decreased 24 hours after surgery （P 〈 0.05）. The Th1/Th2 ratio in control group was significantly lower at postoperative 24 hours compared to that in TAPB group （P 〈 0.05 ）. Conclusion TAP block may increase Thl/Th2 ratio immediatelv after lanamsconic colonic surgery.
作者
谭文斐
任宏伟
金凤
马虹
TAN Wenfei REN Hongwei JIN Feng MA Hong(Department of Anesthesiology, The First Hospital, China Medical University, Shenyang 110001, China)
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2016年第10期898-900,904,共4页
Journal of China Medical University
基金
辽宁省自然科学基金(2014021035)
