摘要
目的探讨磺胺类药物不良反应及应对措施,以提升临床用药的合理性。方法回顾性分析我院2012年6月至2015年6月收治的应用磺胺类药物并发生不良反应(ADR)的125例患者的临床资料,主要统计、分析患者的年龄、性别、服用药物种类、累及器官以及应对措施。结果 125例ADR患者中,中老年患者共有81例,所占比例为64.8%,因此中老年患者为磺胺类药物不良反应多发人群;男性患者共61例,女性患者共64例;磺胺类药物中引发ADR最多的药物为磺胺甲基嘧啶,所占比例为40.8%,其次为磺胺二甲基嘧啶(24.0%)、磺胺间甲基嘧啶(18.4%);不良反应累及器官或系统以过敏反应、消化系统以及泌尿系统为主,过敏反应最为严重,所占比例为37.6%。结论临床应用磺胺类药物时须掌握药物的基本不良反应和交叉过敏机制,严格遵照指导原则,掌握应对措施,以保证安全合理用药。
Objective To investigate the sulfa drug adverse reactions and countermeasures in order to enhance the rationality of clinical medication. Methods One hundred and twenty-five patients clinical data in our hospital from June 2012 to June 2015 were retrospectively analyzed, the application of sulfa drugs and adverse drug reactions （adrs）, the main statistics, the patient＇s age, sex, drug kinds, involving organs as well as the countermeasures were analyzed. Results There were 81 cases elderly patients of 125 ADR cases, which was accounted for 64.8 points , so the old patients were the multiple people in sulfa drug adverse reactions. Of which 61 patients were male, a total of 64 patients were women; sulfanilamide methyl pyridine was the most drugs of Sulfa drug causing ADR, which was accounted for 40.8%, followed by sulfanilamide dimethyl pyridine （24.0%）, sulfanilamide between methyl pyridine （18.4%）; the adverse reactions involving organs or systems were given priority to with allergic reactions, digestive system and urinary system, the most serious adverse was allergic reactions, the proportion was 37.6%. Conclusion The clinical application of sulfa drugs to master basic drug adverse reaction and cross allergic mechanism should strictly follow the guiding principles and control measures, and to ensure safe and rational drug use.
出处
《临床医学研究与实践》
2016年第20期20-21,共2页
Clinical Research and Practice
