摘要
目的调查玉林地区妇女生殖道高危型人乳头瘤病毒（human papilloma virus,HPV）感染与宫颈上皮内瘤病变（cervical intraepithelial neoplasia,CIN）的关系。方法应用导流杂交基因芯片技术（Hybri Max）,对妇科门诊就诊的3 317例有性生活史的妇女,采集宫颈脱落细胞进行HPV分型检测,对检查HPV高危型别阳性者进行宫颈活组织检查。结果自2014年7月至2015年6月期间,共检测我院就诊病例3 317例,检出高危型HPV感染者694例,阳性率为20.92%。对437例进行宫颈活组织检查,CIN 26例,占5.95%（26/437）,其中CINⅡ-Ⅲ12例,占2.74%（12/437）。结论玉林地区妇女高危型HPV感染率及高危型HPV感染者宫颈病变检出率均较高,本地区妇女宫颈上皮内瘤病变常见的高危型HPV类型为HPV16、52、58、18、33。
Objective To investigate the relationships between women high-risk human papilloma virus（HPV） infection and cervical intraepithelial neoplasia（CIN） in Yulin.Methods A total of 3 317 outpatient women with sexual histories were checked for HPV genotyping via DNA flow-through hybridization genotyping technique（Hybri Max）,and then cervical biopsy had was performed among the women with high-risk HPV infection.Results 694 high-risk HPV infections were detected out of 3 317 patients from July 2014 to June 2015,and the positive HPV rate was 20.92%.The cervical biopsy was performed on 437 patients and the proportion of CIN was 5.95%（26/437）,including 12 patients with CINⅡ-Ⅲ（2.74%）.Conclusion The rate of high-risk HPV infection and proportion of CIN among high-risk HPV infector were higher,and general types of high-risk HPV were HPV16,52,58,18,33 in Yulin district.
出处
《分子诊断与治疗杂志》
2016年第5期328-331,340,共5页
Journal of Molecular Diagnostics and Therapy
