摘要
前列腺癌是最常见的男性恶性肿瘤之一。近年来,前列腺癌在我国的发病率呈逐年上升趋势。前列腺癌的早期诊断对指导前列腺癌穿刺、治疗方式以及疾病预后具有直接的影响。目前,前列腺癌筛查的最常用标志物前列腺特异抗原并不是肿瘤特异性标志物,人们发现其用于前列腺癌早期诊断的特异性并不理想,导致了较多不必要的穿刺。因此,获取与前列腺癌高度相关性的肿瘤标志物是现今的研究热点。近年来新发现的长链非编码RNA、单核苷酸多态性及融合基因等分子已被证实与肿瘤具有相关性,可明显提高前列腺癌的诊断效能。本文现就前列腺特异抗原和新发现的几种相关肿瘤标志物在前列腺癌诊断方面的研究进展做一综述。
Prostate cancer（PCa）is one of the most common malignancies in males,and its incidence has increased year by year.The early diagnosis of PCa directly influences the choices of prostate biopsy,treatment and prognosis of the cancer.In fact,prostate specific antigen（PSA）regarded as a common marker in cancer screening isn＇t the specific tumor marker.Its specificity for tumor diagnosis isn＇t satisfactory,so that many unnecessary biopsies occur.Searching for highly specific tumor markers becomes a research hotspot.Nowadays long noncoding RNA（IncRNA）,single nucleotide polymorphisms（SNPs）,fusion gene and other molecular markers have been affirmed to be associated with PCa,so that the diagnostic level of PCa can be obviously improved.This article will focus on research progress of PSA and other new cancer-related markers in diagnosis of PCa.
作者
年新文
任善成
许传亮
孙颖浩
NIAN Xinwen REN Shancheng XU Chuanliang SUN Yinghao(Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, Chin)
出处
《临床泌尿外科杂志》
2016年第9期852-856,共5页
Journal of Clinical Urology
关键词
前列腺癌
早期诊断
分子标志物
prostate cancer
early diagnosis
molecular markers
