摘要
目的:探究二甲双胍与吡格列酮联合治疗2型糖尿病患者的临床效果。方法:选取2015年3月至2016年3月在我院接受治疗的60例2型糖尿病患者,以抽签方式分为治疗组和对照组,各30例,对照组采用二甲双胍治疗,治疗组采用二甲双胍与吡格列酮联合治疗,比较两组患者的治疗效果,体质指数(body mass index,BMI)、糖化血红蛋白(hemoglobin A 1c,HbA_(1c))、糖化白蛋白(glycated albumi,GA)、空腹血糖(fasting blood glucose,FBG)、餐后2h血糖(postprandial 2 hours of blood glucose,2h PBG)、胰高血糖素样肽-1(glucagon like peptide-1,GLP-1)、三酰甘油(triglycerides,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)的改善情况和不良反应。结果:治疗组的治愈率80%,总有效率为93.33%,不良反应例数有2例;对照组的治愈率为53.33%,总有效率为73.4%,不良反应例数有6例;结果显示,治疗组的临床效果优于对照组,BMI、HbA_(1c)、GA、2h PBG、GLP-1、TG、TC、LDL-C、HDL-C的改善情况优于对照组,不良反应发生例数少于对照组,两组差异显著(P<0.05),有统计学意义。结论:二甲双胍与吡格列酮联合治疗2型糖尿病患者具有较好疗效,能够较好地改善患者的BMI、HbA_(1c)、GA、2h PBG、GLP-1、TG、TC、LDL-C、HDL-C,减少患者并发症的发生率,降低患者的复发率,为临床治疗2型糖尿病患者提供较为科学的依据。
Objective： To explore the clinical effect of metformin and pioglitazone combination therapy in the treatment of type 2 diabetes. Methods： A total of60 cases of type 2 diabetic patients in Jinxi County TCM Hospital of Fuzhou City of Jiangxi Province accepted treatment from March 2015 to March 2016 were randomly chosen and divided into treatment group and control group, with 30 cases in each. The control group was treated with metformin, and the treatment group accepted metformin and pioglitazone. The treatment effects were compared between the two groups by body mass index（BMI）, glycosylated hemoglobin（HbA1c）, glycated albumin（GSP）, fasting blood glucose（FBG）, postprandial 2 hours blood glucose（2h PBG）, glucagon hormone like peptide-1（GLP-1）, triglyceride（TG）, total cholesterol（TC）, low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDL-C） to improve the situation and adverse reactions. Results： Treatment group cure rate is 80%, with the total efficiency of 93.33%; and the number of cases of adverse reactions in 2 cases. The control group cure rate is 53.33%, with 73.4% efficiency; and the number of cases of adverse reactions in 6 cases. The results showed, the clinical effects of the treatment group is superior to control group, since the body mass index, glycated hemoglobin, glycated albumin, fasting blood glucose, postprandial 2 Hour blood glucose, glucagon like peptide, triglyceride, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol significantly better than that of the control group, and adverse reaction cases was fewer than that of the control group（P〈0.05）. Conclusions： Metformin and pioglitazone combination therapy in patients with type 2 diabetes mellitus has good curative effect, can better improve the patient body mass index, glycated hemoglobin, glycated albumin, fasting blood glucose, 2-hour postprandial blood glucose, glucagon like peptide, triglyceride, total cholesterol, lo
出处
《药品评价》
CAS
2016年第9期26-28,共3页
Drug Evaluation
