摘要
目的:探讨阿奇霉素治疗小儿难治性肺炎支原体肺炎的疗效。方法:选取沈阳医学院附属第二医院2013年2月—2015年9月收治的112例难治性肺炎支原体肺炎患儿为研究对象,按随机数字表法分为观察组和对照组,每组各56例。观察组患者给予阿奇霉素,对照组给予常规治疗。治疗2周后,比较2组患者的发热持续时间、咳嗽时间、肺部阴影改善情况、住院时间及不良反应发生情况。结果:观察组患者总有效率为82.1%(46/56),明显高于对照组的58.9%(33/56),差异有统计学意义(P<0.05);观察组的发热持续时间、咳嗽时间、住院时间均显著短于对照组,差异有统计学意义(P<0.05)。2组患者不良反应发生率的差异无统计学意义(P>0.05)。结论:阿奇霉素可以减轻难治性肺炎支原体肺炎患儿的痛苦,提高治疗效果,安全性高。
OBJECTIVE： To probe into the efficacy of azithromycin in treatment of refractory mycoplasma pneumoniae pneumonia in children. METHODS： 112 children with refractory mycoplasma pneumoniae pneumonia admitted into the Second Hospital Affiliated to Shenyang Medical College from Feb. 2013 to Set. 2015 were selected to be divided into observation group and control group via the random number table,with 56 cases in each. The observation group were treated with azithromycin,while the observation group received routine therapy. After treatment of two weeks,the duration of fever,cough days,improvement of pulmonary shadow,length of hospital stay and incidence of adverse reactions were compared between two groups. RESULTS： The total effective rate of observation group was 82. 1%（ 46 /56）,significantly higher than that of control group [58. 9%（ 33 /56） ],with statistical significance（ P〈0. 05）. The duration of fever,cough days and length of hospital stay in observation group were significantly shorter than those in control group,with statistical significance（ P〈0. 05）. There was no significant difference between two groups in the incidence of adverse drug reactions（ P〉0. 05）. CONCLUSIONS： Azithromycin can reduce the pain of children with refractory mycoplasma pneumoniae pneumonia and improve the treatment effects with high safety.
出处
《中国医院用药评价与分析》
2016年第9期1191-1193,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
难治性肺炎支原体肺炎
临床特征
阿奇霉素
Refractory mycoplasma pneumoniae pneumonia
Clinical characteristics
Azithromycin
