摘要
目的：系统评价丹参川芎嗪注射液治疗糖尿病周围神经病变的有效性和安全性。方法：计算机检索中国生物医学文献服务系统、中国知网学术文献总库、维普中文生物医学期刊数据库、万方数字化期刊库、Pubmed、Embase和Cochrane Library等数据库,检索时间截至2015年9月。按照Cochrane系统评价方法查找丹参川芎嗪注射液治疗糖尿病周围神经病变的随机对照试验,进行数据库提取和质量评价后,采用Rev Man 5.3软件进行文献荟萃（Meta）分析。结果：与对照组比较,丹参川芎嗪注射液可以明显提高糖尿病周围神经病变患者的治疗总有效率（RR=1.31,95%CI=1.23-1.40,Z=8.09,P〈0.000 01）,并且异质性较小（P=0.41,I2=3%）;对于腓总神经运动传导速度、正中神经运动传导速度、腓总神经感觉传导速度和正中神经感觉传导速度等指标的改善方面,丹参川芎嗪注射液治疗组亦优于对照组,但分析显示,结果的异质性均较高。结论：与其他治疗药物相比,丹参川芎嗪注射液能更好地改善糖尿病周围神经病变的临床结局。
OBJECTIVE：To systematically evaluate the efficacy and safety of Danshenchuanxiongqin injections in treatment of diabetic peripheral neuropathy.METHODS： SinoMed, CNKI, CMJD, CSPD, Pubmed, Embase and Cochrane Library were retrieved by computers till Sept.2015.Randomized controlled trials （ RCTs） of diabetic peripheral neuropathy were searched by Cochrane system evaluation method, after extraction and quality evaluation for database, Rev Man5.3 software was used for data analysis. RESULTS： Compared with control group, Danshenchuanxiongqin injections could significantly increase the total effective rate of patients with diabetic peripheral neuropathy （RR=1.31,95%CI=1.23-1.40,Z=8.09,P〈0.000 01）, with a low heterogeneity（P=0.41, I2 =3%） .Meanwhile, the improvement of motor nerveconduction velocity of common peroneal nerve, median nerve conduction velocity, sensory conduction velocity of common peroneal nerve and median nerve sensory conductionvelocityoutcomes in treatment group were better than that of control group, with a high heterogeneity. CONCLUSIONS：Compared with other treatment drugs, Danshenchuanxiongqin injections can significantly improve the clinical outcomes of diabetic peripheral neuropathy.
出处
《中国医院用药评价与分析》
2016年第8期1076-1080,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
丹参川芎嗪注射液
糖尿病周围神经病变
系统评价
随机对照试验
Danshenchuanxiongqin injections
Diabetic peripheral neuropathy
System evalution
Randomized controlled trials
