摘要
室温条件下,以离子液体为溶剂,利用炔烃与烯烃衍生物发生串联氧化杂环化反应,以中等至优良产率(63%~84%)合成系列官能团化的、饱和的五元含氧杂环化合物.其结构均经IR,1~H NMR,^(13)C NMR及HRMS确证.该串联反应具有反应条件温和、底物适用范围广、环境友好等优点,可为具有饱和的五元含氧杂环化合物的天然产物及复杂药物分子的合成提供简便的途径.
An efficient and practical palladium-catalyzed cascade oxidative heterocyclization has been developed to afford functionalized oxygen-containing five-membered heterocycles in moderate to good yields with high regio- and diastereo-selectivities. Their structures were confirmed by IR, ^1H NMR, ^13C NMR and HRMS. Furthermore, the current methodology could also be conveniently applied to the synthesis of naturally occurring biologically active functionalized tetrahydrofurans and γ-lactones frameworks.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2016年第9期2136-2141,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21502055)
中央高校基本科研业务费(No.2015ZM150)
中国博士后科学基金(No.2015M572303)资助~~
关键词
钯催化
离子液体
炔烃
烯烃
杂环化反应
palladium-catalyzed
ionic liquids
alkynes
alkenes
heterocycles
