摘要
目的探讨小儿肺炎支原体感染合并支气管哮喘患儿血浆中的肿瘤坏死因子-α(TNF-α)与人内皮素-1(ET-1)检测的临床意义。方法选取该院2011年1月-2013年7月间收治的支原体肺炎合并支气管哮喘患儿41例,采用酶免疫吸附法(ELISA)对41例患儿相关的血浆细胞因子ET-1水平、TNF-α水平进行测定,并与30例正常健康儿童对照组比较。观察组中患儿经治疗后症状体征缓解,对其进行8个月的跟踪随访,记录哮喘急性发作的次数以及严重程度。结果 41例肺炎支原体感染患儿在急性发作期以及缓解期的血浆ET-1、TNF-α水平均明显高于正常人群,且与缓解期比较急性发作期的ET-1、TNF-α水平明显升高,以上数据比较差异均有统计学意义(P<0.05)。血浆ET-1水平越高支气管哮喘患儿在进行8个月内的随访中其哮喘的急性发作次数越多,且呈正相关关系(r=0.501,P<0.01)。血浆TNF-α水平越高,支气管哮喘患儿病情的发作程度更严重(r=0.492,P<0.01),8个月内的平均发作程度越重(r=0.449,P<0.01),统计均呈正相关关系。结论支气管哮喘患儿在急性发作期其血浆ET-1以及TNF-α水平升高,与疾病的预后有关:血浆ET-1水平越高,急性发作的次数就越多;血浆TNF-α水平越高,则发作的程度越严重。
Objective To explore the clinical significance of plasma tumor necrosis factor-α （TNF-α） and endothelin-1 （ET-1 ） detection among children with mycoplasma pneumoniae infection combined with bronchial asthma. Methods Forty-one children with myco- plasma pneumoniae infection combined with bronchial asthma treated in the hospital from January 2011 to July 2013 were selected as observa- tion group, ELISA was used to detect the levels of plasma ET-1 and TNF-α, then the results were compared with those in 30 normal healthy children （ control group） . The symptoms and signs of children in observation group were relieved after treatment, then the children were followed up for eight months, the acute onset times and severity of asthma were recorded. Results The levels of plasma ET-1 and TNF-α during acute onset period and remission period in observation group were statistically significantly higher than those in control group （P〈 0.05） . In observation group, the levels of plasma ET-1 and TNF-α during acute onset period were statistically significantly higher than those during remission period （P〈0. 05 ） . The level of plasma ET-1 was positively correlated with acute onset times during follow-up peri- od （ r=0. 501, P〈0. 01 ） . The level of plasma TNF-α was positively con＇elated with severity of acute onset （ r=0. 492, P〈0. 01 ） , and the average severity of acute onset within eight months （r = 0. 449, P〈0. 01 ） . Conclusion The increases of plasma ET-1 and TNF-α levels at acute onset period are correlated with prognosis of children with bronchial asthma： the higher plasma ET-1 level is, the more times of acute onset is ; the higher plasma TNF-α level is, the higher degree of severity of acute onset is.
出处
《中国妇幼保健》
CAS
2016年第19期3968-3970,共3页
Maternal and Child Health Care of China
