摘要
肿瘤是一种基因疾病,其发病机制包括单核苷酸突变、拷贝数变异、插入/缺失等。人类对肿瘤经过数十年的研究,未获得突破性进展。肿瘤研究的关键是理解基因的改变在肿瘤发生、发展过程中发挥的作用。近些年单细胞测序技术的发展为探寻肿瘤发生中基因的改变提供了有力的工具。现通过肿瘤标志运用流式细胞术分选单个肿瘤细胞,并通过细胞测序获得大量信息,为肿瘤的治疗提出一个新方法—个体化治疗。
As a genomic disease, cancer involves a series of changes in the genome. These genomic alterations include copy number variations （CNVs）, single-nucleotide variations （SNVs）, and insertions/deletions （INDELs）. Regardless of the concentrated efforts in the past decades, the key driving genomic alterations responsible for can- cer are still elusive. The key of cancer research is how do the changes work. In recent years, the development of Sequencing single cancer cell provides a powerful tool to devise the changes of cancer. Cells were captured with the flow cytometry using tumor maker, genomic analyses of single cancer cell could provide more pertinent information and a new kind of method to personalized treatment of cancer.
作者
李晓洁
LI Xiao-jie(Taizhou Polytechnic College, Taizhou Jiangsu 225300, Chin)
出处
《泰州职业技术学院学报》
2016年第4期62-64,68,共4页
Journal of Taizhou Polytechnic College
基金
2013年度江苏省卫生职业技术教育研究立项课题(J201310
课题负责人:李晓洁)
关键词
测序
肿瘤
个体化治疗
拷贝数变异
sequencing
tumor
personalized therapy
copy number variations（CNVs）
