摘要
目的:应用近红外漫反射技术建立洛伐他汀胶囊一致性检验模型快检方法。方法:收集洛伐他汀胶囊的近红外漫反射光谱,运用OPUS软件建立洛伐他汀胶囊一致性快速比对模型,并用三台不同仪器和不同厂家该品种对模型进行验证。结果:模型通过仪器交叉验证,也能区分出其他厂生产的异烟肼,利用该洛伐他汀胶囊一致性检验模型能无损伤、准确、快速地鉴定洛伐他汀胶囊的真伪。结论:该方法建立的模型操作简单、快速有效,能作为洛伐他汀胶囊真伪鉴别的快速筛选方法。
Objective：To establish the near infrared diffuse reflectance spectroscopy method to perform conformity test of Lovastatin capsules.Methods：Near-infrared spectra（NIR） was used to set up the conformity test model by the OPUS software.Three instruments using cross-validation of the model,And with other manufacturers to validate the model of Lovastatin capsules.Results：Model through the instrument cross-validation, but also to distinguish it opened production plants Lovastatin capsules, the use of the consistency test model can no damage, quickly and accurately determine the authenticity of Lovastatin capsules.Conclusion：The method to establish a simple model of operation, fast and effective, able to identify the authenticity of the piece as Lovastatin capsules rapid screening methods.
出处
《北方药学》
2016年第10期4-5,共2页
Journal of North Pharmacy
