摘要
引起乙型肝炎病毒(hepatitis B virus,HBV)感染后慢性化的因素有宿主因素和病毒因素。宿主因素主要有免疫功能、细胞凋亡蛋白抑制因子(cellular inhibitor of apoptosis proteins,c IAPs)以及HLA基因多态性等使宿主不能产生有效的抗病毒反应;病毒因素主要包括乙肝病毒基因型、乙肝病毒变异、乙肝病毒抗原等,导致HBV持续存在肝细胞中不能被清除。本文综合最新国内外进展对乙肝病毒感染后慢性化的发生机制进行综述。
The risks of chronicity following HBV infection include host and virus factors. The host factors include immunity, cellular inhibitor of apoptosis proteins （clAPs）, human leukocyte antigen genes polymorpfiism and so on, wfiich lead to non-effective antiviral response. The viral factors that may affect the viral clearance include hepatitis B virus genotype, hepatitis B virus mutation, hepatitis B virus antigen and so on. This paper reviews the latest progress of chronic hepatitis B virus infection mechanisms at nation and abroad.
出处
《中国热带医学》
CAS
2016年第8期836-838,共3页
China Tropical Medicine
基金
深圳市科技创新委员会资助项目(No.JCYJ20120616144140857)
