摘要
咽喉反流性疾病（laryngopharyngeal reflux disease, LPRD）是指一组因胃内容物异常反流至食管上括约肌以上的咽喉部而引起的一系列临床症候群。人体具有多个抗反流相关屏障，包括下食管括约肌、膈肌脚、膈食管韧带等构成的高压带，食管体部的蠕动和酸廓清能力，上食管括约肌，咽喉部黏膜的自然抵抗力等。上食管括约肌在咽喉反流中发挥着屏障作用，然而上食管括约肌功能障碍是否是导致咽喉反流的原因至今还未明确。本文就国内外的一些相关研究进行讨论。
Laryngopharyngeal reflux disease （LPRD） is believed to be caused by retrograde flow of gastric contents （particularly acid and pepsin） that affect pharyngeal and laryngeal mucosa by direct contact or by a secondary mechanism. Human body has a series of anti reflux barrier, including high pressure zone composed of lower esophageal sphincter and the crural diaphragm and phrenoesophageal ligament, esophageal body motility and acid clearance ability, upper esophageal sphincter, resistance of throat mucous. Upper esophageal sphincter plays a role of barrier in the LPRD, however, it is not clear whether the upper esophageal sphincter dysfunction causes the LPRD. In this paper, some related research at home and abroad are discussed.
出处
《国际耳鼻咽喉头颈外科杂志》
2016年第5期282-285,共4页
International Journal of Otolaryngology-Head and Neck Surgery
关键词
咽喉反流
食管括约肌
上段
laryngopharyngeal reflux
Esophageal Sphincter, Upper
