摘要
终末分化细胞可以通过重编程和转分化转变为其他类型的细胞,对再生医学领域的研究有重要意义。化学小分子由于结构多样性,及作用剂量、时间的可控性,其在重编程和转分化领域的应用前景广阔。我国科学家在该方向的研究中也取得了许多引人瞩目的成就。对体细胞重编程和转分化的方式、小分子化合物在体细胞重编程研究领域的应用以及全化学诱导体细胞重编程和转分化研究的最新进展,尤其是我国科学家在本领域的进展进行综述。
Differentiated somatic cells can be transformed back into pluripotent state or into other types of cells by reprogramming and trans-differentiation, and may provide functional cells for regenerative medicine. Due to their structural versatility and being easy of application in time- and concentration-dependent ways, small molecule compounds are highly useful in inducing somatic cell reprogramming or trans-differentiation. In this review, we summarize the recent progresses in full chemical-mediated reprogramming and trans-differentiation.
作者
付艳宾
龙媛
谢欣
FU Yan-Bin LONG Yuan XIE Xin(Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China CAS Key Laboratory of Receptor Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China)
出处
《生命科学》
CSCD
2016年第8期941-948,共8页
Chinese Bulletin of Life Sciences
基金
中国科学院“干细胞与再生医学研究”战略性先导科技专项(XDA01040301)
干细胞研究国家重大科学研究计划(2015CB964503)
国家自然科学基金项目(81425024,31371511)
关键词
小分子化合物
体细胞重编程
诱导性多能干细胞
转分化
small molecules
somatic cell reprogramming
induced pluripotent stem cell
trans-differentiation
