摘要
目的探讨黏膜型恶性黑色素瘤(MucMM)的临床病理学特征。方法观察21例MucMM的临床病理特征,复习文献。结果 21例MucMM,男性略多于女性,平均年龄62.9岁,平均发病时间3.4个月。瘤细胞形态呈大间变性上皮样、痣细胞样、透明细胞样、圆细胞样、梭形等,色素多少不等或无,核仁明显,核分裂象多,可见病理性核分裂象。随访9个月-10年,平均复发/转移的时间为24.3个月,平均生存时间为52.2个月,2年存活率为47.6%,5年存活率为19%。结论 MucMM较其他类型的恶性黑色素瘤,具有不同的临床、病理和分子遗传学特征,生物学行为更具侵袭性,起源和危险的环境因素还未确知。
Objective To study the clinicopathological features of mucosal malignant melanoma（ Muc MM）. Methods 21 cases of Muc MM were analyzed with review of the literature. Results Men were slightly more than women in 21 cases of Muc MM,the average age was 62. 9 years,and the average onset time was 3. 4 months. Histological morphology of the tumor cells included anaplastic large epithelioid,nervus cell-like,clear cell-like,round,spindle,and mixed epitheliod and spindle cell features. There were seen melanin pigment and increased melanophages in tumors,and sometimes amelanotic. The cells always had significantly eosinophilic nucleoli and numerous mitotic figures. Follow-up ranged from 9months to 10 years,the average recurrence or metastasis time was 24. 3 months,the average survival time was 52. 2 months,2-year survival rate was 47. 6%,and 5-year survival rate was 19. 0%. Conclusions Muc MM has distinct different clinical,epidemiological,genetic features,and a more aggressive clinical pattern. There have not yet been identified the genetic and environmental risk factors which drive mucosal melanomagenesis.
作者
赵燕
刘福兴
卢婷
窦荣荣
ZHAO Yan;LIU Fu-xing LU Ting DOU Rong-rong(Department of Pathology, Taizhou People＇s Hospital, Taizhou 225300, Chin)
出处
《诊断病理学杂志》
CSCD
2016年第9期650-654,共5页
Chinese Journal of Diagnostic Pathology
基金
江苏省卫生厅科技发展基金项目(201456)
