摘要
目的：比较不同术式对结直肠癌效果及免疫功能的影响。方法选择焦作市人民医院2014年3月至2015年6月收治的结直肠癌患者95例，根据患者自愿原则将其分为观察组55例和对照组40例。对照组采用传统开腹术，观察组采用腹腔镜下根治术。比较两组手术时间、术中出血量、术后排气时间、并发症发生率和住院时间，并测定术前和术后3 d血清免疫球蛋白A（IgA）、血清免疫球蛋白G（IgG）、血清免疫球蛋白M（IgM）和C-反应蛋白（CRP）水平。结果观察组术中出血量、术后排气时间、术后CRP水平、住院时间、并发症发生率分别为（182.6±44.5）ml、（40.4±13.4）h、（36.2±14.7）mg/L、（11.2±3.6）d、9.09%（5/55），显著低于对照组（t或χ^2=7.894、7.258、6.447、5.167、4.408，P〈0.05）。观察组术后IgA、IgG、IgM水平分别为（2.7±0.5）g/L、（10.0±1.3）g/L、（1.24±0.12）g/L，显著高于对照组（t=4.183、4.226、4.340，P〈0.05）。结论相比于传统开腹术，腹腔镜下根治术具有更好的效果，对结直肠癌患者免疫功能影响更小，值得临床推广应用。
Objective To investigate the result of different operation and the influence on the immune function in treating colorectal cancer.Methods 95 cases with colorectal cancer were divided into observation group （n=55） and control group （n=40） according to the patients＇ willing. The control group was treated with traditional laparotomy while the observation group was treated with laparoscopic radical operation. The operation time, bleeding volume, postoperative exhaust time, complication rate and hospitalization time of two groups were compared, and the serum levels of IgA, IgM, IgG and CRP were determined before and 3d after operation.Results The amount of bleeding, postoperative exhaust time, postoperative CRP levels, hospital time, and complications occurred rate of observation group were respectively （182.6±44.5） ml, （40.4±13.4） h, （36.2±14.7） mg/L, （11.2±3.6） days, 9.09%（5/55）,which were significantly lower than those of the control group （t orχ^2=7.894,7.258,6.447,5.167,4.408,P〈0.05）. The levels of IgG, IgM and IgA in the observation group were （2.7±0.5） g/L, （10.0±1.3） g/L, （1.24±0.12） g/L, which were significantly higher than those of the control group （t=4.183,4.226,4.340,P〈0.05）.Conclusions Compared with traditional laparotomy, radical resection under laparoscopic has better effect and less influence on immune function in patients with colorectal cancer, which is worthy of clinical application.
出处
《中国临床实用医学》
2016年第4期7-9,共3页
China Clinical Practical Medicine
关键词
结直肠癌根治术
腹腔镜
开腹术
免疫功能
Radical resection of colorectal cancer
Laparoscopic
Laparotomy
Immune function
