摘要
目的探讨质子泵抑制剂(PPIs)和结肠息肉形成两者间的关系。方法将本院结肠息肉的患者设为病例组(154例),肠炎及未见异常者设为对照组(98例)。调查所有入组人员饮食及生活习惯、PPIs服用等情况,并测定血胃泌素水平。各因素先进行单因素分析,有统计学意义者进一步行多因素Logistic回归。结果单因素分析提示PPIs与结肠息肉的发生及生长部位有关(P<0.05),结肠息肉组中服用PPIs的患者与未服用PPIs患者的胃泌素水平有显著差异[(115±19.4)ng/Lvs(66.4±8.4)ng/L],P<0.001),但病例组与对照组两者间胃泌素水平无明显差异(P=0.191,P>0.05),且进一步多因素Logistic分析提示PPIs变量无统计学意义(P=0.081,P>0.05)。结论本研究无法证实与结肠息肉形成是否存在必然相关性,PPIs与结肠息肉之间是否存在关联尚待进一步研究。
Objective To study the relationship of proton pump inhibitors and the growth of colonic polyps. Methods A total of 154 patients who underwent colonoscopy in our hospital were as patients group and 98 healthy cases were as controls. Dietary and life style factors and family history of two groups were investigated. And serum gastrin levels were examined in all patients. Suspected variables were screened by univariate analysis and those with statistical significant were further ana- lyzed by multivariate conditional Logistic regression. Results PPIs was found to be correlated with the growth of colonic polyps and growth distribution （ P 〈 0.05 ）. In patients with colonic polyps, the mean gastrin level in PPI users versus non-PPI users was （ 115 ± 19.4 ） ng/L versus （ 66.4 ± 8.4） ng/L,respectively （P 〈 0. 001 ）, but there was no difference in serum gastrin levels in two groups（ P = 0. 191, P 〉 0.05 ）. Further multivariate conditional Logistic regression analysis demon- strated that there was no significant difference in variable PPIs. Conclusion The research cannot confirm that PPIs is related to the growth of colonic polyps, and it remains further exploration.
出处
《实用临床医药杂志》
CAS
2016年第17期50-52,共3页
Journal of Clinical Medicine in Practice
