摘要
目的 探讨中国北方地区汉族人群内皮素受体（EDNR）A和EDNRB基因中单核苷酸多态性（SNP）与缺血性脑卒中（IS）的相关性。方法 检测EDNRA基因的3个位点：rs1801708、rs5333、rs5335和EDNRB基因的2个位点：rs3818416、rs5351在对照组、IS组中的多态分布。结果在男性群体中,EDNRA基因rs5335位点突变纯合型CC发病危险度明显降低（P=0.016;OR=0.52;95%CI=0.31~0.88）;在女性群体中,EDNRA基因rs1801708位点中,突变纯合型AA发病危险度明显高于G基因携带者（P=0.019;OR=2.65;95%CI=1.18~6.00）。结论 EDNRA基因rs5335位点的C等位基因能够降低北方汉族男性人群IS的发病风险,rs1801708位点的A等位基因能够增加北方汉族女性人群IS的发病风险。
Objective To investigate the association between SNP polymorphisms of endothelin receptor （ EDNRA and EDNRB） gene and ischemic stroke （IS） in the Chinese Han population in northern.Methods The SNPs,including rs1801708,rs5333,and rs5335 in EDNRA gene and rs3818416 and rs5351 in EDNRB gene,were analyzed and calculated their polymorphic distribution.Results In male pop-ulation,EDNRA gene mutation rs5335 homozygous CC morbidity risk was significantly lower （P=0.016;OR 0.52;95%CI 0.31~0.88）. In the female population,the mutant homozygous AA cancer risk was significantly higher than G allele carriers （P=0.019;OR 2.65;95%CI 1.18~6.00） on ENDRA gene rs1801708.Conclusions In EDNRA gene,C allele of rs5335 might reduce the IS incidence risk factors in Northern Han male population.A allele of rs1801708 in EDNRA gene could increase the risk of IS in Northern Han women population.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2016年第18期4446-4449,共4页
Chinese Journal of Gerontology
基金
国家自然科学基金(No.81371461)
