摘要
目的探讨重度宫腔粘连(intrauterine adhesion,IUA)患者于宫腔镜宫腔粘连分离术(transcervical resection of adhesions,TCRA)前应用戊酸雌二醇预防宫腔再粘连的疗效。方法选取因重度IUA行分离术的96例患者,按术前是否用药分为预处理组46例:于手术前3个月连续口服戊酸雌二醇(补佳乐)2 mg,1次/d,最后10 d加用黄体酮0.1 g,2次/d,出血撤退后手术;术后连续口服21 d戊酸雌二醇1 mg,3次/d,最后5 d加用黄体酮胶丸0.1 g,2次/d口服,人工周期治疗。对照组50例:术前不予处理,术后治疗与预处理组一致。随访两组术后月经改善情况、宫腔再粘连情况及妊娠情况。结果两组宫腔再粘连率比较差异有统计学意义(P<0.05),月经改善率及妊娠率比较差异无统计学意义(P>0.05)。结论重度IUA患者TCRA术前应用戊酸雌二醇预处理对预防宫腔再粘连有一定作用。
Objective To investigate the effectiveness of estradiol valerate（E2V） in preventing re-adhesions in patients of severe adhesions before trans-cervical resection of adhesions（TCRA）.Methods 96 patients with severe intrauterine adhesions were to be treated with TCRA from September 2012 to September 2014 in Maternal and Child Health Hospital of Zhengzhou.They were divided into pretreatment group（with 46 cases） and control group（with 50 cases）.Pretreatment group took E2V（2 mg/qd,po） orally for 3months before the operation,and added progesterone（0.1g/bid,po） in the last10 days.When bleeding retreat conducted the TCRA,and then began artificial cycle treatment（E2 V 1mg/tid,po,for 21 days,progesterone soft capsules 0.1g/bid,po,for the last 5days）after the operation.The control group went without pretreatment.Menstruation improvement,re-adhesions,pregnancy situations of the two groups were compared after TCRA.Results The re-adhesions rate of the two groups had statistical significant difference（P〈0.05）.There were no statistical significant differences of menstruation improvement rate and pregnancy rate between the two groups（P〉0.05）.Conclusion E2 V have an effect on preventing re-adhesions on patients of severe adhesions before TCRA and is worthy of clinical application.
出处
《中国计划生育和妇产科》
2016年第9期42-45,共4页
Chinese Journal of Family Planning & Gynecotokology
关键词
重度宫腔粘连
宫腔粘连分离
人工周期
severe intrauterine adhesions
trans-cervical resection of adhesions（TCRA）
artificial cycle treatment
