摘要
目的探讨2型糖尿病(T2DM)合并急性脑梗死(acute brain infarction,ABI)患者血清超敏C-反应蛋白(hs-CRP)、尿酸(UA)水平以及血液流变学各指标联合检测的诊断价值。方法选择2013年2月至2015年10月接受诊治的ABI患者141例为观察组,观察组患者根据其是否患有T2DM,分为T2DM组53例,非T2DM组88例,选择同期门诊排除的健康体检者55例作为对照组。测定hs-CRP和UA水平以及血液流变学各指标。结果观察组患者hs-CRP和UA水平明显高于对照组(P<0.05);观察组中,T2DM组的hs-CRP和UA水平明显高于非T2DM组(P<0.05);观察组患者血液流变学各指标明显高于对照组(P<0.05);观察组中,T2DM组血液流变学各指标明显高于非T2DM组(P<0.05);腔隙性脑梗死组、小梗死组、大梗死组患者hs-CRP、UA水平以及血液流变学各指标依次升高,差异有统计学意义(P<0.05),并随着其神经功能损伤程度的加重而升高,差异有统计学意义(P<0.05);hs-CRP和UA水平均与血液流变学各指标呈正相关,差异有统计学意义(P<0.05)。结论 T2DM合并ABI患者血清hsCRP、UA水平水平以及血液流变学各指标与其脑梗塞面积和神经功能缺损程度密切相关,并对患者病情具有一定的临床诊断价值。
Objective To investigate the diagnostic value of combination detection of high-sensitivity C-reactive protein（ Hs-CRP）,uric acid（ UA） with hemorheological indexes in patients with type 2 diabetes mellitus（ T2DM）complicated by acute cerebral infarction（ AMI）. Methods One hundred and forty-one patients with ABI who were admitted and treated in our hospital from February 2013 to October 2015 were selected as observation group,and according to whether the patients suffered from T2 DM,these patients were divided into T2 DM group（ n = 53） and non-T2 DM group（ n = 88）,besides 55 healthy subjects were served as control group. The levels of hs-CRP,UA and hemorheological indexes were detected and compared between two groups. Results The levels of hs-CRP and UA in observation groups were significantly higher than those in control group（ P〈0. 05）,moreover,which in T2 DM group were obviously higher than those in non-T2 DM group（ P〈0. 05）. The hemorheological indexes in observation groups were significantly higher than those in control group（ P〈0. 05）,furthermore,which in T2 DM group were obviously higher than those in non-T2 DM group（ P〈0. 05）. The levels of hs-CRP and UA in lacunar cerebral infarction group,small infarction group and large infarction group,and the hemorheological indexes were increased in order,there were significant differences among the three groups（ P〈0. 05）,moreover,which were increased with the severity of neurologic impairment（ P〈0. 05）. Besides the levels of hs-CRP and UA were positively correlated to those of hemorheological indexes（ P〈0. 05）. Conclusion The levels of hs-CRP,UA and hemorheological indexes are closely correlated to cerebral infarction area and severity of neurologic impairment in patients with type 2 diabetes mellitus complicated by acute cerebral infarction,which has certain clinical significance in evaluating the pathogenetic condition of patients.
出处
《河北医药》
CAS
2016年第19期2911-2914,共4页
Hebei Medical Journal
