摘要
目的:探究胰瘅贴外敷对重症急性胰腺炎(SAP)模型大鼠胃肠动力的影响及其可能机制。方法:雄性SD大鼠36只,随机分为3组:假手术组(J组,n=12)、重症急性胰腺炎模型组(M组,n=12)及胰瘅贴治疗组(Z组,n=12)。48h后观察各组大鼠胰腺组织病理变化、胃排空率、小肠推进率及血清胃动素浓度。结果:胰腺病理学评分提示M组和Z组大鼠胰腺坏死严重,显著高于J组(P<0.01)。M组大鼠的胃排空率低于J组,差异有显著统计学意义(P<0.01)。J组大鼠的小肠推进率高于M组和Z组,差异有显著统计学意义(P<0.01);M组大鼠的小肠推进率低于Z组,差异有统计学意义(P<0.05)。J组大鼠的血清MTL浓度高于M组与Z组,差异有显著统计学意义(P<0.01);Z组大鼠的血清MTL浓度高于M组,差异有显著统计学意义(P<0.01)。大鼠血清MTL浓度与小肠推进率相关性分析提示二者呈正相关关系(r=0.798,P<0.01)。结论:胰瘅贴外敷可以改善SAP大鼠小肠推进率,促进肠道动力的恢复,其机制可能与调节血清胃动素的分泌有关。
Objective： Observing the effect of external application of＂YIDANTIE＂ treating severe acute pancreatitis （SAP） rats on serum motilin, gastric emptying rate, intestinal impelling rate, and then discussing the pathogenesis of gastrointestinal motility disorder in SAP rats. Methods：Divided 36 male healthy SD rats into 3 groups by random allocation, group J：sham-operation group, group M： SAP model control group, group Z：＂YIDANTIE＂treat group. After 48 hours of surgery, all rats were detected the motilin, measure the damage score of pancreas by pathological section; count gastric emptying rate（GER） and Intestinal propulsive rate. Results.. Group M and Z have remarkable higher grading than group J, which difference has statistical significance（P〈0.01）;group M has lower rate than group J , the difference has statistical significance Remarkable （P〈0. 01） ;compared group M and Z with group J, the rate of intestinal impelling was much lower, which has statistical significance（P〈0. 01）, group Z was higher than group M, which did has statistical significance（P〈0. 05）. Much lower level of serum MTL can be seen compared group M/Z with group J, statistical significance was significant （P〈0. 01） ;group Z has higher serum MTL than group M, which had statistical significance （P〈0. 01）. The concentration of Serum motilin was positively correlated to intestinal impelling rate（r=0. 798;P〈0. 01）. Conclusion： ＂YIDANTIE＂ could improve the gastrointestinal motility in SAP rat, and Its mechanism may be related to the secretion of MTL.
出处
《医学理论与实践》
2016年第18期3153-3154,3162,共3页
The Journal of Medical Theory and Practice
基金
泸州医学院-泸州医学院附属中医医院联合科研基金,泸医院科(2013)63号
关键词
重症急性胰腺炎
胰瘅贴
胃肠动力
Severe acute pancreatitis, YIDANTIE,Gastrointestinal motility
