摘要
目的观察内镜下精准靶向植入缓释化疗粒子治疗进展期食管癌的临床疗效。方法在内镜直视下,将病灶以1.0 cm的层间距分为若干层,每层内以每间隔1.0 cm种植一枚缓释化疗粒子;植入时每点植入10 mg,依病情需要,每4周植入1次,种植3次为1个疗程。此项研究中全部病患均顺利完成治疗。通过比对研究患者在治疗前、治疗后3个月及治疗后6个月的临床症状缓解情况、病灶面积变化情况、吞咽困难改善情况、不良反应和生活质量等。结果治疗前分别与治疗3和6个月比较,患者病变面积、吞咽困难分级变化差异有统计学意义(P<0.05);但生活质量改善情况差异无统计学意义(P>0.05,原因可能是随访时间较短及样本量较少,未体现出个体之间差异);另外治疗前与治疗3个月白细胞(WBC)差异有统计学意义(P<0.05);治疗前、治疗3和6个月并发症情况发生率差异无统计学意义。结论内镜下植入5-氟尿嘧啶(5-Fu)缓释粒子治疗晚期食管癌,是一种安全有效、毒副作用小和耐受性好的姑息治疗方法。
Objective To observe the clinical effects by endoscopic implantation of accurate and slow-release particles for advanced esophageal carcinoma. Methods Under endoscopy, we dividing the whole focus into several layers by each 1.0 cm and implanting one slow-release particles （about 10 mg） in each point whose interval is 1.0 cm. One course of treatment includes three-time implantation and each treatment needs four weeks, by the way the details depend on the state of illness. In this research, all of patients complete the treatment smoothly. By comparing the patients＇ situation before treatment, three-month treatment and six-month treatment, which include the remission of clinical symptom, the changing of focus area, the improvement of swallow function, untoward effect and life quality, et al. Results The results show several test indexes changed a lot. When treated for 3 months and 6 months, the levels of focus area and swallow difficulty classification were decreased significantly （P 〈 0.05） as compared with those before treatment; but the patients＇ life quality didn＇t have significant statistical difference （P 〉 0.05）, by the way there isn＇t individual difference appearing because of a little short of testing time and a few of samples. In addition, the WBC had a significant statistical difference between before treatment and three-month treatment （P 〈 0.05）, and the ratio of complication didn＇t have a significant change. Conclusions Endoscopic implantation of 5-Fu slow-release particles for the treatment of advanced esophageal carcinoma is a safety, high efficacy, low toxic and good tolerant palliative treatment.
出处
《中国内镜杂志》
北大核心
2016年第9期30-34,共5页
China Journal of Endoscopy
关键词
食管癌
5-FU
精准靶向缓释化疗粒子植入
esophageal carcinoma
5-Fu
implantation of accurate and slow-release particles
