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左西孟旦治疗老年难治性心力衰竭的血流动力学改变和临床疗效 被引量:8

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摘要 目的:观察左西孟旦治疗老年难治性心力衰竭的临床表现、血流动力学、脑钠肽变化。方法应用左西孟旦治疗老年难治性心力衰竭患者25例,观察治疗前后临床表现的变化,并测定血流动力学和脑钠肽指标。结果25例患者中,显效13例,有效7例,无效5例,总有效率为80%(20/25)。应用左西孟旦治疗前后各指标变化情况:治疗前后心率、平均动脉压比较差异无统计学意义(P>0.05);治疗24 h后和治疗1周后心输出量(CO)、心脏指数(CI)均较治疗前明显提高[(4.59±0.64)和(4.55±0.54) L/min 比(3.31±0.62) L/min、(3.00±0.32)和(3.03±0.30) L/(min·/m2)比(2.14±0.23)L/(min/m2)],肺毛细血管楔压(PCWP)、中心静脉压(CVP)和脑钠肽均较治疗前明显下降[(15.32±2.12)和(16.22±2.32)mmHg(1 mmHg=0.133 kPa)比(20.40±3.15) mmHg、(6.87±1.58)和(6.69±1.68) mmHg 比(9.26±3.16) mmHg、(620.6±305.6)和(600.8±289.6)ng/L比(1201.4±750.6)ng/L],差异有统计学意义(P<0.05)。应用左西孟旦后,2例出现恶心、不适感,但不影响治疗;1例发生室性期前收缩,经纠正低钾血症后消失。结论左西孟旦治疗老年难治性心力衰竭安全有效。
出处 《中国医师进修杂志》 2016年第9期850-852,共3页 Chinese Journal of Postgraduates of Medicine
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