摘要
目的观察甘氨双唑钠(CM-Na)联合同步放化疗治疗非小细胞肺癌(NSCLC)合并肺不张患者的増敏疗效及副作用。方法将90例初诊为NSCLC患者按随机分组原则分为増敏组(甘氨双唑钠+同步放化疗)和对照组(同步放化疗),每组45例。对照组采用调强放疗(IMRT)+化疗,放疗总剂量(DT):60~70 Gy;鳞癌患者化疗采用紫杉醇+奈达铂(TP)方案,腺癌患者化疗采用培美曲塞+顺铂(PP)方案。増敏组在同步放化疗的基础上予甘氨双唑钠,每次800 mg/m^2,30 min内经静脉滴注完,在60 min内行放疗,每周一、三、五给药,至放疗结束。结果増敏组和观察组在放疗过程中因为肺复张需要重新进行CT定位时的患者数分别为44例、36例,放疗中位剂量分别为36.16、47.04 Gy,两组比较差异均具有统计学意义(P<0.05)。増敏组和观察组患者治疗结束时肿瘤原发灶有效率(CR+PR率)分别为97.8%、86.6%,纵膈淋巴结有效率分别为100%、91.1%,两组比较差异有统计学意义(P<0.05)。放射性肺炎等毒副反应两组比较差异无统计学意义。结论甘氨双唑钠联合同步放化疗能提高非小细胞肺癌合并肺不张患者的近期疗效,同时又不增加毒副反应,但是远期疗效及毒副反应也需进一步随访观察。
【Objective】To observe the sensitivity and side-effect of sodium glyci-didazole（CM-Na） combined with concurrent radiochemotherapy for non-small cell lung cancer（NSCLC） with atelectasis.【Methods】Ninety cases of new diagnosed NSCLC patients were randomly divided into sensitizer group（CM-Na plus concurrent radiochemotherapy） and control group（concurrent radiochemotherapy） with 45 cases in each group. The control group took intensity-modulated radiotherapy（IMRT） plus chemotherapy, and total dose（DT） of radiotherapy was 60~70 Gy; chemotherapy regimen was taxol plus nedaplatin（TP） in patients with squamous carcinoma; chemotherapy regimen was pemetrexed and cisplatin（PP） in patients with adenocarcinoma. Additionally, the sensitizer group was treated with CM-Na（800 mg/m^2 intravenous infusion within 30 min）, after which radiotherapy was administered within 60 min on Monday, Wednesday and Friday every week till the end of the radiotherapy.【Results】The number of patients in the sensitizer group and the control group respectively were 44 and 36 when computed tomography（CT） simulation was needed again in the course of radiotherapy because of lung recruitment, the median radiation dose were 36.16 Gy and 47.04 Gy respectively, and the differences between the two groups were statistically significant（P〈 0.05）. For primary lesion, the total effective rates, which was the sum of complete release（CR） rate and partial release（PR） rate in sensitizer group and in control group were 97.8% and 86.6% respectively; the CR＋PR rates of mediastinum metastatic lesion in the two groups were 100% and 91.1% respectively; the differences were statistically significant between the two groups（P〈 0.05）. There was no significant difference in toxicity like radiation pneumonitis in the two groups（P〉 0.05）.【Conclusion】CM-Na combined with concurrent radiochemotheraphy for NSCLC with atelectasis can increase the short-term therapeutic response without obvious toxicity, bu
出处
《中国医学工程》
2016年第8期14-17,共4页
China Medical Engineering
关键词
甘氨双唑钠
肺肿瘤
非小细胞肺癌
同步放化疗
肺不张
sodium glyci-didazole
lung cancer
non-small cell lung cancer
concurrent radiochemotherapy
atelectasis
