摘要
目的:观察调气消积方对乳腺癌内分泌治疗患者疗效及内分泌综合征的影响。方法:将104例乳腺癌术后内分泌治疗患者按数字表法随机分为两组,两组内分泌治疗均选用他莫昔芬,对照组52例出现内分泌综合征者给予谷维素治疗,观察组52例自治疗开始联合给予调气消积方,6个月后以乳腺癌患者生命质量测定量表(QLQ-BR53)对生活质量进行评价,观察中医症状、性激素血清水平变化情况评价内分泌综合征,并统计不良反应评价安全性,长期随访根据无病生存期评价综合疗效。结果:观察组QLQ-BR53评分中,症状、乳腺癌特异性类目评分低于对照组,总体健康状态类目评分高于对照组,差异均有统计学意义(P<0.05);观察组中医症状评分治疗前后差值、促卵泡生成素血清水平等明显低于对照组,雌二醇血清水平明显高于对照组,差异有统计学意义(P<0.05);随访期内,观察组无病生存期(1.87±0.39)a,对照组为(1.61±0.31)a,两组比较差异有统计学意义(P<0.05)。结论:调气消积方可显著降低乳腺癌内分泌治疗患者内分泌综合征发生风险或病情程度,改善患者生命质量,提高综合疗效。
Objective ： To observe the effect of regulating Qi and eliminating accumulation prescription on the curative effect and endocrine syndrome of breast cancer patients with endocrine therapy. Methods ： 104 cases of breast cancer patients with endocrine therapy were randomly divided into the observation group and the control group, and the two groups were both given tamoxifen. The control group （52 cases） with endocrine syndrome was given oryzanol,the observation group （52 cases） since the beginning of therapy in combination with the administration of regulating Qi and eliminating accumulation prescription. After 6 months, quality of life were evaluated with breast cancer measurement scale （QLQ-R53）. To observe the changes levels of TCM syndrome and serum of sex hormones for evaluation of endocrine syndrome, and statistical toxicity evaluation of safety, long-term follow-up according to the disease free survival for evaluation of the comprehensive efficacy. Results：In the observation group, QLQ-BR53 score, symptoms, breast cancer specific category score lower than control group, overall health status category score was higher than that of the control group, the differences were statistically significant （ P 〈 0.05 ） ; in the observation group, difference value of TCM syndrome score before and after treatment, the serum levels of follicle stimulating hormone were significantly lower than those of control group, estradiol serum levels was significantly higher than the control group, the difference was statistically significant （ P 〈 0.05 ） ;during the follow-up period,the average of disease-free survival in the observation group was （ 1.87 ±0.39）years,and the control group was （ 1.61 ± 0. 31 ） years, the difference between the two groups was statistically significant （P 〈 0.05）, Conclusion： Regulating Qi and eliminating accumulation prescription can significantly reduce the incidence of endocrine therapy in breast cancer patients with endocrine syndrome risk or disease de
出处
《中医学报》
CAS
2016年第8期1086-1088,共3页
Acta Chinese Medicine
基金
河南省重点科技攻关项目(082102310028)
关键词
乳腺癌
内分泌治疗
他莫昔芬
调气消积方
生活质量
肿瘤
中医药治疗
breast cancer
endocrine therapy
tamoxifen
regulating Qi and eliminating accumulation prescription
quality of life
tumor
TCM therapy
