摘要
[目的]探讨超级伽玛刀在腹部晚期肿瘤中的应用价值。[方法]对本院肿瘤外科收治的130例腹部晚期肿瘤患者采用伽玛刀进行治疗，3～6Gy／次，5次／周，总治疗次数6～15次，总治疗剂量36～55Gy的周期治疗，对不同类型肿瘤治疗的疗效及治疗后不良反应进行比较。[结果]治疗后患者卡氏功能状态（KPS）评分为（85．02土1．02）分，较治疗前（55．01±1．38）分显著增加，且治疗前后相比较差异具有显著性（P〈0．05）；治疗后患者的肿瘤有较显著的缩小，且治疗后患者临床症状显著缓解，近期总有效率达到了93．07％（121／130）；治疗后患者的整体疗效与其肿瘤体积（GTV）大小相关（P〈0．01）；患者治疗副作用主要以胃肠道功能受到影响为主，主要不良反应有恶心、腹泻、腹痛、呕吐，均经对症治疗后有效缓解。[结论]超级伽玛刀治疗腹部晚期肿瘤患者临床疗效较好，且安全可靠，其在腹部晚期肿瘤治疗中具有较好的应用价值。
[Objective]To explore the application value of super gamma knife on late stage abdominal tumors. [Methods] One hundred and thirty cases of late stage abdominal tumor patients were selected as the research objects and underwent gamma knife treatmentof 3--6Gy/time, 5 times / week, with a total of 6 to 15 treatments and a total treatment dose of 36--55Gy. By means of suitable radiotherapy via super gamma knife in different types of late stage abdominal tumor patients, treatment efficacy and adverse reactions were ob- served and compared. [Results] The results showed that after treatment, the patient activity and function score evaluated byKPS （karnofsky performance status scale） was （85.02 ± 1.02） points compared to before treatment （55.01±1.38） points, which was a significant increase with statistical significance （ P〈0.05）. After treatment, the tumors in patients showed significant shrink and clinical symptoms of the patients were significantly alleviated with treatment response efficiency 93.07 % （121/130）. After treatment, the patients overall efficacy had a close relation with the global tumor volume （GTV, P〈0.01）. Side effects after-treatment mainly affected gastrointestinal function; And the main adverse reactionslike nausea, diarrhea, abdominal pain, and vomiting, were effectively alleviated through symptomatic treatment.[Conclusion] The super gamma knife has a significant positive effect on patients with advanced abdominal tumor. It is safe and reliable, and has a wide range of clinical application value.
出处
《医学临床研究》
CAS
2016年第8期1570-1572,共3页
Journal of Clinical Research
