摘要
目的探讨恩替卡韦与干扰素α-2b联合治疗慢性乙型肝炎(CHB)的临床疗效以及对免疫功能的影响,为提高治疗效果提供理论依据。方法选取2013年1月-2015年1月在医院接受治疗的108例CHB患者作为研究对象,将患者随机分为对照组和试验组,每组各54例,在抗乙型肝炎病毒(HBV)感染治疗的基础上,对照组患者采用恩替卡韦治疗,试验组采用恩替卡韦联合干扰素α-2b治疗,比较两组患者治疗前后的肝功能及乙型肝炎病毒脱氧核糖核酸(HBV-DNA)值的变化。结果治疗6个月后,试验组患者的丙氨酸氨基转移酶(ALT)复常率、HBV-DNA阴转率、乙型肝炎病毒E抗原(HBeAg)阴转率与对照组比较,差异无统计学意义;治疗12个月后,两组患者上述指标比较,差异均有统计学意义(P<0.05);试验组患者的治疗总有效率为88.89%,明显高于对照组,差异有统计学意义(P<0.05);治疗后试验组患者的CD4+、CD8+水平明显高于对照组,CD4+/CD8+的比值明显高于对照组(P<0.05)。结论采用恩替卡韦与干扰素α-2b联合治疗CHB比单独使用恩替卡韦药物治疗效果更明显,可有效改善患者的肝功能,提高其机体的免疫能力。
OBJECTIVE To explore the clinical effect of entecavir combined with interferonα-2bon treatment of patients with chronic hepatitis B（CHB）and observe the influence on immune function so as to provide theoretical basis for improvement of curative effect.METHODS A total of 108 CHB patients who were treated in hospitals from Jan 2013 to Jan 2015 were recruited as the study objects and randomly divided into the control group and the experimental group,with 54 cases in each group.On the basis of treatment of HBV infection,the control group was treated with entecavir,while the experimental group was given entecavir combined with interferonα-2b.The liver function and value of hepatitis B virus deoxyribonucleic acid（HBV-DNA）were observed and compared between the two groups of patients before and after the treatment.RESULTS There was no significant difference in the normalization rate of alanine aminotransferase,negative conversion rate of HBV-DNA,or negative conversion rate of hepatitis B virus E antigen（HBeAg）between the experimental group and the control group after the treatment for 6months;however,there was significant difference in the above indexes between the two groups of patients after the treatment for 12months（P〈0.05）.The total effective rate of treatment of the experimental group was 88.89%,significantly higher than that of the control group（P〈0.05）.The levels of CD4^＋and CD8^＋of the observation group were significantly higher than those of the control group after the treatment;the CD4^＋/CD8^＋ratio of the experimental group was significantly higher than that of the control group（P〈0.05）.CONCLUSION Entecavir combined with interferonα-2bcan achieve more remarkable effect on treatment of CHB than single entecavir,and it can effectively improve the liver function and boost the body′s immunity.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第17期3895-3897,共3页
Chinese Journal of Nosocomiology
基金
山东省自然科学基金资助项目(30225039)
