摘要
小胶质细胞是中枢神经系统中重要的神经免疫细胞,当中枢神经系统受到刺激后,小胶质细胞通过炎症反应来应对这种刺激,这种炎症反应在神经性疾病中具有重要作用。研究发现,小胶质细胞自噬在炎症的发生与发展中也发挥了重要作用,它能直接或间接地影响炎症反应,同时自身也被其他信号调控。自噬过程有利有弊,适当的自噬过程能促进疾病的恢复,自噬紊乱则使病情恶化,所以明确自噬的调控机制对治疗和预防相关疾病具有重要意义。本文综述了近年来自噬在小胶质细胞相关炎症中研究进展,以及其可能的调控机制,以期为相关研究人员提供一定帮助。
Microglia is a kind of neural immune cell in central nervous system（ CNS）. When CNS is stimulated by internal or external stimulus,inflammation reaction of microglia will be induced to reply the stimulation,which plays an important role in neurological diseases. It is proposed that autophagy of microglia has an essential effect on the process of inflammation,which can influence inflammation reaction directly or indirectly. At the same time microglia will be regulated by other signals. Autophagy has both advantages and disadvantages,and favorable autophagy process can contribute to the recovery of disease,while disorder autophagy may cause deterioration. Therefore,illuminating the exact regulatory mechanism of autophagy is of great significance to the treatment and prevention of related diseases.Herein,recent advances about the role of autophagy in microglia related to inflammation and its possible mechanisms were reviewed to provide some help to related researchers.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2016年第9期976-983,共8页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金项目(No.81373429
81070973
81671243)
大连金州新区科技计划项目(No.KJCX-ZTPY-2014-0014)资助~~
关键词
小胶质细胞
神经炎症
自噬
microglia
neuroinflammation
autophagy
