摘要
目的观察胸腺五肽联合化疗治疗肺癌的临床效果及对ET-1、T淋巴细胞亚群水平的影响。方法选取2012年10月—2015年10月内蒙古自治区人民医院肿瘤内科收治的肺癌患者116例作为研究对象,按随机数字表法分为观察组58例和对照组58例。2组患者在化疗前给予止吐、预防静脉炎及水化利尿等常规治疗,小细胞肺癌采用EP化疗方案,非小细胞肺癌采用TP化疗方案。观察组在对照组化疗基础上联合应用胸腺五肽10 mg肌内注射,1次/d。疗程均为15d,共4个疗程。观察2组患者的临床效果、化疗前后呼气冷凝液及血清ET-1,血清ALB、CD4^+、CD8^+、CD4^+/CD8^+及NK的水平变化情况,采用EORTC QLQ-C30生存质量问卷调查表进行评分,并记录消化道不良反应发生情况。结果化疗后观察组总有效率明显高于对照组(63.8%vs.56.9%,χ~2=4.772,P=0.029),呼气冷凝液及血清ET-1水平低于对照组,血清ALB、CD4^+、CD8^+、CD4^+/CD8^+及NK水平、生存质量评分均显著高于对照组(t=18.193、15.405、5.031、5.676、2.532、4.901、7.577,P=0.000、0.000、0.000、0.000、0.006、0.000、0.000);观察组消化道反应发生率为15.5%,显著低于对照组的39.6%(χ~2=8.458,P=0.004)。结论胸腺五肽联合化疗治疗肺癌疗效确切,可降低呼气冷凝液及血清ET-1水平,抑制肿瘤转移程度,提高机体免疫功能,改善患者的生存质量。
Objective To observe the clinical effect of thymic peptide combined with chemotherapy in the treatment of lung cancer and its effect on the levels of ET-1 and T lymphocyte subtypes .Methods One 116 cases of patients with lung cancer were selected , which were treated in hospital from October 2012 to October 2015 , and they were divided into the obser-vation group （58 cases） and control group （58 cases）.The patients of two groups were treated with Antiemetic , diuretic hy-dration and prevention of phlebitis before chemotherapy .The patients of control group with small cell lung cancer were treated with EP chemotherapy .The patients of control group with non-small cell lung cancer were treated with TP chemotherapy .On the basis of control group, the patients of observation group were treated with thymopentin （ 10 mg, intramuscular injection , 1 times /d, continuous application for 15d）.A course of treatment were 15d, and with a total of four courses.Observe the clinic results, occurrence of adverse reactions , EORTC QLQ-C30 quality of life questionnaire score , changes of serum and EBC ET-1,serum ALB, CD4 ＋, CD8 ＋, CD4 ＋/CD8 ＋, NK of two groups.Results After chemotherapy, the patients of the observation group got a total efficiency of 63.8%, which was significantly better than the 56.9%of the control group （χ^2 =4.772, P =0.029）; In the terms of ET-1, the patients of two groups were all significantly decreased than before （ P 〈0.05）, and the patients of the observation group got more significant decline （ t =18.193, t=15.405, P =0.000, P =0.000）;In the terms of ALB, CD4^＋, CD8^＋, CD4^＋/CD8^＋, NK and QOL, the patients of two groups were all significantly improved than before （ P 〈0.05）, and the patients of the observation group got more significant improvement （ t =5.031, t =5.676, t =2.532, t =4.901, t =7.577;P =0.000, P =0.000, P =0.006, P =0.000, P =0.000）;the patients of the observation group got a incidence of gastrointestinal reactions of 15.5%, which was si
出处
《疑难病杂志》
CAS
2016年第9期896-899,共4页
Chinese Journal of Difficult and Complicated Cases
