摘要
早产儿视网膜病变（retinopathyofprematurity，ROP）是早产儿及低体重儿发生的一种异常新生血管形成和纤维组织增生性视网膜病变，被视为引起儿童视觉受损的重要疾病之一，严重病例可导致视力永久丧失。国内外大量研究发现ROP影响视网膜的发育及功能，主要影响感光细胞，且临床研究发现这种视网膜功能障碍既使早期得到控制，后续仍易发生屈光不正，尤其是近视。最新研究发现氧诱导小鼠视网膜病变（oxygeninducedinducedretinopathy，01R）的神经视网膜功能障碍可能与OIR诱导多巴胺（dopamine，DA）释放和活性的变化有关。ROP患儿早期出现近视及近视发生率高与ROP影响视网膜多巴胺的分泌及释放密切相关，深入探讨DA在ROP近视中的作用将为临床ROP患儿中近视防治提供新的思路。
Retinopathy of prematurity （ROP） is a kind of abnormal neovaseularization and fibrous tissue proliferation retinopathy in premature and low birth weight infants. It is regarded as one of the impor- tant diseases causing visual impairment in children, which can lead to permanent visual loss. A large num- ber of domestic and foreign study found that ROP affected retinal development and function, mainly affected the light-sensitive cells, and clinical study found that the retinal dysfunction even early controlled, usually following the ametropia, especially myopia. Recent studies have found that oxygen induced retinopathy （OIR） retinal dysfunction may be related to the release of dopamine （DA） and the changes in the activity of DA. Studies found that ROP early myopia and the high incidence of myopia in children with ROP were close- ly related to the effect of ROP on the secretion and release of dopamine in the retina. Therefore, discussing the role of DA in ROP myopia will provide a new way of thinking for the prevention and treatment of myopia in children with ROP. （
出处
《国际眼科纵览》
2016年第4期258-262,共5页
International Review of Ophthalmology
