摘要
以3-巯基丙酸（MPA）为稳定剂,利用水相合成法合成具有独特光学性质的Mn掺杂Zn S量子点（QDs）,基于该量子点的室温磷光性质建立了一种高效、灵敏的检测抗癌药物顺铂（cisplatin,DDP）的新方法。该量子点在室温不除氧的条件下即可发射较强的磷光信号。在p H=7.4的磷酸盐缓冲液中,顺铂作为良好的电子受体,能够通过光诱导电子转移（PIET）原理猝灭Mn掺杂Zn S量子点的室温磷光（RTP）。在最优实验条件下,该方法的线性范围为2.5~50μmol/L,相关系数R=0.99,检出限为0.85μmol/L。
Using 3-mercaptopropionic acid（ MPA） as the stabilizer,MPA-capped Mn-doped ZnS QDs are synthesized via water phase method. Based on the room temperature phosphorescence properties of quantum dots,a highperformance and high-sensitivity method is estabilished for detection of anti-cancer drugs cisplatin（ DDP）. A strong room-temperature phosphorescence emission of the Mn-doped Zn S QDs is observed without existence of deoxidants and other inducers. In the phosphate buffer of p H 7. 4,the room temperature phosphorescence（ RTP） of Mn-doped quantum dots are quenched through photoinduced electron transfer principle with DDP as the good electron acceptor. Under the optimal conditions,this method has a DDP detection limit of 0. 85 μmol/L and linear range from 2. 5 to 50 μmol/L（ correlation coefficient R = 0. 99）.
出处
《现代化工》
CAS
CSCD
北大核心
2016年第8期200-203,205,共5页
Modern Chemical Industry
基金
山西省重点化学优势学科建设项目(912019)
国家教育部博士点联合基金项目(20111404110002)
关键词
Mn掺杂Zn
S量子点
室温磷光猝灭
顺铂
Mn-doped ZnS QDs
room-temperature phosphorescence quenching
cisplatin
