摘要
On the basis of the proposed structures of jiangrines C and D, a synthetic strategy was initiated from D-glyceraldehyde acetonide,a readily available chiral material. Through a linear seven-step synthesis, the target molecules were accomplished. However, all characteristic data of the synthetic 3 and 4 were found to be different from those of natural jiangrines C and D. Accordingly, the molecular structures of jiangrines should be revised and a possible molecular skeleton for them was proposed.
On the basis of the proposed structures ofjiangrines C and D, a synthetic strategy was initiated from D-glyceraldehyde acetonide, a readily available chiral material. Through a linear seven-step synthesis, the target molecules were accomplished. However, all characteristic data of the synthetic 3 and 4 were found to be different from those of natural jiangrines C and D. Accordingly, the molecular structures ofjiangrines should be revised and a possible molecular skeleton for them was proposed.
作者
Zhijiang Zhang
Bo Liu
Zhijiang Zhang;Bo Liu(Key Laboratory of Green Chemistry & Technology of Ministry of Education,College of Chemistry, Sichuan University, Chengdu 610064, China;State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China)
基金
supported by the National Natural Science Foundation of China (21290180, 21322205, 21321061)
the Open Fund of State Key Laboratory of Natural Medicines (SKLNMKF201601)
