摘要
目的探讨维生素E辅助治疗对癫痫患者血浆总抗氧化力(T-Aoc)、丙二醛(MDA)水平的影响。方法选择从2012年12月至2014年12月进行治疗的癫痫患儿90例,每组45例,随机分为观察组和对照组。对照组给予常规抗癫痫药物治疗,观察组在此基础上辅助应用维生素E治疗。观察并对比两组患儿的治疗效果和血浆T-Aoc、MDA水平。结果观察组患者总有效率为97.8%,高于对照组的总有效率84.4%,差异具有统计学意义(P<0.05);治疗后观察组T-Aoc明显高于治疗前[(17.58±2.13)U/ml vs.(14.23±1.43)U/ml],MDA低于治疗前[(35.97±3.86)mmol/L vs.(44.09±4.87)mmol/L],差异具有统计学意义(P<0.05);对照组T-Aoc、MDA治疗前后变化不显著[(14.02±1.53)U/ml vs.(14.58±1.63)U/ml;(44.98±4.80)mmol/L vs.(43.02±4.26)mmol/L],差异无统计学意义(P>0.05)。治疗后组间比较观察组T-Aoc水平更高,MDA水平更低,差异具有统计学意义(P<0.05)。结论在癫痫的治疗中辅助用维生素E可显著提高患者血浆的T-Aoc水平,并显著减低MDA水平,临床疗效显著,具有较高的应用价值。
Objective To analyse and explore the adjuvant treatment influence of vitamin E on serum total antioxidant （T - Aoc）, malon- dialdehyde （MDA） level in patients with epilepsy. Methods From December 2012 to December 2014 90 children with epilepsy in our hospital were selected, and were randomly divided into observation group and control group, 45 cases in every group. The control group were given conventional antiepileptic drug therapy, based on which the observation group were treated with auxiliary application vitamin E treatment. Observe and compare the therapeutic effect of two groups of children. Results The total effective rate in observation group was 97. 8% , which was higher than the total efficiency of 84. 4% in the control group, and the difference was statistically significant （ P 〈 0. 05） ; After treatment T - Aoc observation group was significantly higher than before treatment [（17. 58 ± 2.13） U/ml vs. （14.23±1.43） U/ml] , MDA was lower than before treatment [（35. 97 ±3.86） mmol/L vs. （44. 09 ±4. 87） mmol/L] , the difference was statistically significant （ P 〈 0. 0 5 ） . But T - Aoc, MDA before and after treatment in the control group has no significant change [（14. 02 ± 1 . 53） U/ ml vs. （14.58±1.63） U/ml; （44. 98 ±4. 80） mmol/L vs. （43. 02 ±4. 26） mmol/L] , the difference was not statistically significant （ P 〉 0. 0 5 ） . The level of T - Aoc in the observation group was higher and MDA level was lower than those in the control group, the difference was statistically significant （ P 〈 0 . 0 5 ） . Conclusion In the treatment of epilepsy, treatment regimen assisted with vitamin E can significantly improve patients serum levels of T - Aoc, and significantly reduce the MDA level, and has significant clinical effect. It is worthy of promoting.
出处
《临床和实验医学杂志》
2016年第17期1703-1705,共3页
Journal of Clinical and Experimental Medicine
