摘要
应用植物化学物(phytochemicals)调控Nrf2/ARE通路成为预防和治疗氧化应激相关疾病的靶点。在十字花科植物中存在的天然强抗氧化剂莱菔硫烷在体内和体外具有广泛的神经保护作用,近期研究表明,其对Nrf2/ARE通路的调控作用介导其神经保护作用。笔者就莱菔硫烷通过调控Nrf2/ARE通路的神经保护作用研究进展进行综述。
Nrf2/ARE pathway has become an attractive target using phytochemicals for the prevention and treatment of oxidative stress-related diseases including neurodegenerative diseases, such as Alzheimer＇s disease（ AD）, and Parkinson＇s disease（PD）. Among phytochemicals, sulforaphane （SFN） has demonstrated neuroprotective effects in several in vitro and in vivo studies. In particular, evidence suggests that beneficial effects of SFN could be mainly ascribed to its peculiar ability to activate the Nrf2/ARE pathway. There-fore, SFN appears to be a promising compound with neuroproteetive properties that may play an important role in preventing neurode-generation. This contribution focuses on Nrf2/ARE-mediated signaling pathways, particularly in relation to neuroprotective effects of sulforaphane.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2016年第17期1445-1449,共5页
Chinese Pharmaceutical Journal
基金
国家自然科学基金资助项目(81260196
81450036)
内蒙古自治区高等学校青年科技英才支持计划资助项目(NJYT-13-B20)
中国博士后科学基金资助项目(2015M570974)
内蒙古自然科学基金资助项目(2014MS0892
2014BS0802
2014MS0814
2015BS0812
2013MS1176)
内蒙古自治区人才开发基金资助项目
"内蒙古自治区青年创新人才"计划资助项目
内蒙古自治区新世纪321人才工程计划资助项目
内蒙古"草原英才"计划资助项目
内蒙古自治区高等学校科学研究项目(NJZY234
NJZZ12306
NJZZ14271)
内蒙古人类遗传病研究重点实验室项目
内蒙古教育厅高校创新平台培育项目
