摘要
[Objective] This study aimed to investigate the elimination regularity of ronidazole residues in chickens. [Method] Normal, healthy, 85-day-old Jinling broilers were selected as experimental chickens and fed with complete feed containing different concentrations of ronidazole. Ronidazole residues in chicken feather and edible tissues were detected by high performance liquid chromatography-tandem mass spectrometry （LC-MS/MS） method to compare the elimination regularity. [Result] Data analysis showed that the amount of ronidazole residues in chicken feather and edible tissues was positively correlated with the concentration of ronidazole administered. After drug withdrawal, there was a significant correlation between the elimination of ronidazole residues in chicken feather and edible tissues. Thus, the prediction model of ronidazole residues in chicken feather could be established. [Conclusion] This study could improve in vivo detection system of ronidazole residues and provide reference for monitoring and controlling drug residues in livestock and poultry oroduction.
[目的]探讨洛硝哒唑在鸡体内的残留消除规律.[方法]采用广西地方鸡种质资源选育而成的金陵花鸡,挑取同一背景,健康正常85日龄为实验用鸡通过使用拌料加入不同浓度洛硝哒唑的方法,分别饲养同一批处于生长期的肉鸡,利用液相色谱-串联质谱技术检测鸡毛及可食组织中的洛硝哒唑残留,比较其残留消除规律.[结果]通过数据分析研究表明,洛硝达唑在鸡毛、鸡可食组织中的残留随饲喂量的增加呈正相关,停药后洛硝达唑在鸡毛、鸡可食组织中的残留消除有显著的相关性,可建立鸡毛中洛硝达唑残留预测模。[结论以期完善洛硝哒唑残留活体检测体系,为养殖动物活体药残监控提供参考。
基金
广西科技厅科技攻关项目(桂科重1222003-2-2)~~
