摘要
目的:探讨药物引起固定性药疹的一般规律及特点,为临床诊断与治疗固定性药疹提供参考。方法:利用《中国期刊全文数据库》(CNKI),检索1994年10月-2014年10月国内外公开发表的关于药物引起固定性药疹的个案报道的文献,并进行分类统计、分析。结果:剔除因不明药物或合并用药导致固定性药疹的文献、重复报道以及给药错误等的文献后,筛选出符合要求的文献100篇,共103例。苯巴比妥钠14例,所占比例最大(13.59%)。男性多发于生殖器,女性多发于四肢,多发生于用药后的24h内。结论:对于伴有药物过敏史,在使用抗感染药物等其他药物后24h内出现全身多部位或单部位的圆形红斑,可伴有瘙痒,应高度警惕,可能是发生了固定性药疹。应详细询问药物过敏史,停用可疑致敏药物,加用抗组胺药和应用皮质类固醇以直接缓解症状。
Objective：To discuss the general pattern and feature of the fixed drug eruption（FDE）induced by drugs,so as to provide reference to rational use of drugs clinically.Methods：Literature related to cases of drug-induced FDE reported from October,1994 to October,2014 was retrieved from the Chinese Journal Full-text Database and CNKI,and the obtained documents were sorted and analyzed statistically.Results：With the rejection of those documents about FDE induced by unknown drugs or combined medication,repeated documents and those documents about FDE induced by wrong medication,100 papers that met the requirements were screened out,with a total of 103 cases.There were 14 cases of phenobarbital sodium-induced FDE,which accounted the largest proportion（13.59%）.The eruption mostly occurred in the genitalia for the male and in the limbs for the female,and in most cases within 24 hours after medication.Conclusion：For those with history of drug allergy,it should be highly aware that FDE might have occurred,if circular erythema accompanying with itching displayed on the whole body or multi areas of the body or just one area of the body,after 24 hours of medication of antibacterials and other drugs.In this case,inquiries should be made on the history of drug allergy,the suspected allergic drug should be withdrawn,and antihistamines and steroids should be applied to relieve the symptoms of the patient.
出处
《药学服务与研究》
CAS
2016年第4期288-290,共3页
Pharmaceutical Care and Research
关键词
固定性药疹
药物副反应报告系统
文献分析
合理用药
fixed drug eruption
adverse drug reaction reporting systems
literature analysis
rational use of drugs
