摘要
目的探讨干细胞关键转录因子OCT4在膀胱癌患者组织中的表达与临床病理因素及预后的相关性。方法选取河北大学附属医院病理科收集的73例经泌尿外科手术切除的膀胱癌组织(膀胱癌组)及30例癌旁组织(癌旁组)作为标本进行免疫组化染色观察,对比两种OCT4蛋白的表达程度,并分析其与患者的临床病理特征及远期预后的关系。结果膀胱癌组织中OCT4蛋白的阳性表达率(71.23%)显著高于癌旁组织(10.00%)(P<0.05);膀胱癌组织中OCT4蛋白的阳性表达与膀胱癌分化程度、发生血管淋巴结转移、浸润深度有关(P<0.05),与年龄、性别、病理分期无关(P>0.05);膀胱癌组织中OCT4蛋白的阳性表达3年生存率显著低于阴性表达(P<0.05),3年生存中位时间显著短于阴性表达(P<0.05)。结论 OCT4表达与膀胱癌转移有关,对远期预后具有不良影响。
Objective To investigate expression of key transcription factor OCT4 in tissues of patients with bladder cancer and its correlation with clinicopathological factors and prognosis. Methods A total of 73 cases of bladder cancer tissues by surgical ablation（ group A） and 30 cases of adjacent tissues（ group B） were collected as specimens for immunohistochemisty staining. In group A and B,expression of OCT4 protein were compared,and correlation of OCT4 protein expression with clinicopathologic feature and its long-term outcome were also analyzed. Results Positive expression rate of OCT4 protein in group A（ 71. 23%） was significantly higher than 10. 00% in group B（ P 〈0. 05）. In group A,positive expression of OCT4 protein was related with differentiated degree of bladder cancer,lymphaden metastasis and infiltrated depth（ P〈 0. 05）; but it was not related with differences of age,gender and pathological stage（ P 〉0. 05）; 3-year survival rate in positive expression of OCT4 protein was significantly lower than that in negative expression of OCT4 protein（ P〈 0. 05）,and 3-year meta-survival time in positive expression was significantly shorter than that negative expression one（ P 〈0. 05）. Conclusion OCT4 expression has correlation with bladder cancer metastasis,and it has adverse effects on long-term outcome.
出处
《解放军医药杂志》
CAS
2016年第8期19-22,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
膀胱癌
干细胞关键转录因子OCT4
临床病理因素
预后
Bladder cancer
Stem cells key transcription factors OCT4
Clinicopathologic factor
Prognosis
