摘要
目的比较不同剂量替米沙坦治疗老年高血压伴慢性肾脏病的临床疗效。方法选取2014年1月-2015年12月内科收治的老年高血压伴慢性肾脏病患者60例,随机分为替米沙坦常规剂量组40mg/d和双倍剂量组80mg/d,各30例,持续治疗12周。于治疗结束后比较两组患者治疗前后血压、24h尿蛋白变化及血钾、血肌酐水平。结果两组患者治疗后血压及24h尿蛋白均有所降低,双倍剂量组降低水平更优于常规剂量组(P<0.05);双倍剂量组降低尿蛋白有效率为93.3%,高于对照组83.3%的有效率,组间比较有显著性差异(P<0.05)。结论替米沙坦是一种具有降压及保护肾脏功能作用的临床药物,选用双倍剂量应用可以进一步提高降压和减少尿蛋白的疗效。
Objective To compare the clinical effect of different dose of telmisartan in the treatment of hypertension accompany with chronic kidney disease in elderly people. Methods 60 cases of elderly people who had hypertension accompany with chronic kidney disease were selected from January 2014 to December 2015, and then divided into general group with 40mg/d of telmisartan and double dose group with 80mg/d, 30 patients in each group and received the treatment for 12 weeks. Items included blood pressure, urine protein changes in 24 hours as well as the level of serum kalium and creatinine. Results The blood pressure and urine protein in 24 hours of the two groups were all decreased, the decreased degree of the double dose group was better than the general group（P〈0.05）, the effective rate in the double dose group was 93.3%, which was higher than 83.3% in the general group and had statistical difference（P〈0.05）. Conclusions Telmisartan is a kind of drug which had both blood pressure decreasing and kidney protection function, the application of double dose of the drug could improve the treatment effect of decreasing blood pressure and urine protein at the same time.
出处
《中国病案》
2016年第7期F0002-F0002,F0003,共2页
Chinese Medical Record
关键词
替米沙坦
不同剂量
高血压
慢性肾脏病
Telmisartan
Different dose
Hypertension
Chronic kidney disease
