摘要
2,5-二甲氧基苯基乙胺是一种有机合成中间体,在医药和精细化工行业具有重要价值。系统研究有机均相催化体系中以负载型催化剂Ru/AC和Ru-Pd/AC对2-(2,5-二甲氧基苯基)硝基乙烯进行催化加氢制备2,5-二甲氧基苯基乙胺。结果表明,采用Ru/AC催化体系,在氢压5.0 MPa、Ru浓度4.9×10-3mol·L^(-1)、反应时间5 h和反应温度150℃条件下,可以获得纯度较高的CC加氢与硝基完全加氢的目标产物,转化率达到100%,目标产物选择性可达93%;采用Ru-Pd/AC催化体系,在氢压3.0 MPa、Ru和Pd总浓度2.46×10-3mol·L^(-1)、反应时间5 h和反应温度190℃条件下,转化率可以达到100%,目标产物选择性为84%。反应结束后,抽滤即可分离催化剂和产物。
2,5-Dimethoxyphenethylamine （DMPEA） as an important intermediate in organic synthesis is widely used in fine chemicals and pharmaceutical industries. In this paper, the performances of supported catalysts Ru/C and Ru-Pd/C for catalytic hydrogenation of 2-（ 2,5-dimethoxy phenyl ） nitroethylene （DMPNE） to prepare DMPEA in organic homogeneous phase catalytic system were studied. The results showed that in Ru/C catalytic system, the target compound with high purity was obtained by selective catalytic hydrogenation of both C=C and nitro groups under the reaction condition of H2 pressure 5.0 MPa, Ru concentration 4.9 x 10 -3 mol ·L-1, reaction time 5 h and reaction temperature 150 ℃, and DMPNE conversion and the selectivity to the target product were 100% and 93% ,respectively. DMPNE conversion of 100% and the selectivity to the target product of 84% were attained under the optimal reaction condition as follows ： Ru-Pb/AC catalytic system, H2 pressure 3.0 MPa, Ru ＋ Pd concentration 2.46 x 10-3 mol ·L-1 ,reaction time 5 h and reaction temperature 190 ℃. After the reaction, it was easy to separate the hydrogenation product from the catalyst by air pump filtration.
出处
《工业催化》
CAS
2016年第8期78-82,共5页
Industrial Catalysis
