摘要
目的了解水源性高碘不同水碘分型地区育龄妇女甲状腺疾病患病情况,探讨水碘分型与妇女甲状腺功能和甲状腺疾病的关系。方法采用描述流行病学横断面对比研究方法,2014年在山西省高碘地区水碘含量150-300μg/L、>300μg/L两个范围各选水碘含量相同但碘分型不同(I^-、IO_3^-)的2个村作为调查点,4村共抽取18-45岁育龄妇女180例,记录一般资料,采集随机1次尿样、家庭生活饮用水水样及静脉血。实验室以砷铈催化分光光度法检测水碘、尿碘含量,全自动化学发光免疫分析法检测血清游离三碘甲状腺原氨酸(FT_3)、游离甲状腺激素(FT_4)、促甲状腺素(TSH),放射免疫法检测血清甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TGAb)。结果 (1)相同水碘水平不同碘分型组间比较:IO3-150组育龄妇女尿碘值≥300μg/L者比例高于I-150组妇女(χ~2=6.352,P<0.05);IO3-300组育龄妇女的尿碘水平、尿碘值≥800μg/L者比例及血甲状腺自身抗体总阳性率均高于I-300组(Z=-1.995,P<0.05;χ~2=6.116,P<0.05;χ~2=3.829,P<0.05)。(2)不同水碘水平相同碘分型组间比较:I-300组育龄妇女的尿碘水平、尿碘值≥300μg/L者比例均高于I-150组(Z=-4.045,P<0.01;χ~2=7.988,P<0.01);IO3-300组育龄妇女的尿碘水平、尿碘值≥800μg/L者比例均高于IO3-150组(Z=-4.973,P<0.01;χ2=14.239,P<0.01),且妇女甲功TSH异常值率、甲状腺自身抗体阳性率、亚临床甲减患病率高于IO3-150组妇女(χ~2分别为5.490、6.501、3.936,P<0.05)。结论水源性高碘地区育龄妇女的甲状腺功能异常可能与生活饮用水水碘分型有关,水碘总量和水碘分型两者对妇女甲状腺功能可能存在叠加作用,建议加强高碘地区妇女碘营养及甲状腺功能监测。
Objective To understand the prevalence of thyroid diseases of fertile women in different iodine intake and different iodine type areas,to investigate the influence of iodine type for women＇s thyroid gland function and autoimmune.Method Adopt cross section method for descriptive epidemiology,collecting 180 women aged from 18 to 45 years for reproductive life in Shanxi province in 2014.Design and fill in questionnaire,record common data for place,name,age,contact way and so on,get random urine for one time,water sample at home and theirs venous blood,and then detect the iodine contents for water and urine in arsenic and cerium catalysis spectrophotometric method,finally detect FT_3,FT_4,TSH in the blood in auto-CLIA,and also detect Ant I-TPO and Anti-Tg in the blood in radio-immunity.Result（ 1） The comparison results between groups in regions with the same level of water iodine but different iodine types：In IO3-150 group of women,the ratio of urinary iodine ≥ 300 μg / L is higher than I-150 group of women（ χ2 6.352,P 〈0.05）.In IO3-300 group of women,both the median of urinary iodine and the ratio of urinary iodine ≥ 800 μg / L is higher than I-300 group of women,and the rate of women＇s thyroid dysfunction with positive antibodies was obviously higher than those in I-300 group（ Z =-1.995,P 〈0.05;χ2= 6.116,P 〈0.05;χ2 3.829,P 〈0.05）.（ 2） The comparison results between groups in regions with the same iodine type but different level of water iodine：In I-300 group of women,both the median of urinary iodine and the ratio of urinary iodine ≥ 300 μg / L is higher than I-150 group of women（ Z =-4.045,P〈 0.01;χ2 7.988,P〈 0.01）.In IO3-300 group of women,both the median of urinary iodine and the ratio of urinary iodine ≥ 800 μg / L is also higher than IO_3～-150 group of women（ Z =- 4.973,P〈 0.01;χ2 14.239,P〈 0.01）.And also the rate of thyroid dysfunction and the morbidity rate of inferior clinical hypothyroidism for women was obviously higher than those in IO_3�
出处
《中国地方病防治》
CAS
北大核心
2016年第5期485-488,共4页
Chinese Journal of Control of Endemic Diseases
基金
山西省卫生厅科研课题计划项目(20131076)
关键词
碘
过量
碘离子
碘酸根离子
营养
甲状腺疾病
育龄妇女
Iodine
Excess
Iodine ions
Iodate radicals
Nutrition
Thyroid disease
Fertile women
