摘要
目的探讨分次口服PEG的方案能否在取得良好肠道清洁效果的同时减少患者的不良反应。方法纳入2015年6月至2015年12月我院行结直肠镜检查的患者,采用电脑随机数生成的方式患者分为分次组(n=104)及单次组(n=103),分次组肠道准备肠道准备采用PEG-ES分次分剂量服用,单次组采用PEG-ES单次全剂量服用。比较两组患者进镜时间、Boston肠道准备量表(boston bowel preparationscale,BBPS)评分、不良反应。结果分次组进镜时间平均为(12.1±4.6)min,单次组进镜时间平均为(11.9±5.3)min,两组患者相比差异无统计学意义(t=0.29,P=0.77)。分次组BBPS评分平均为(7.4±2.2)min,单次组BBPS评分平均为(6.5±1.9)min,分次组BBPS评分优于单次组,差异有统计学意义(t=3.15,P=0.00)。进一步行Ridit分析,结果显示分次组的良、优所占百分比显著高于单次组,差异有统计学意义(u=2.39,P=0.02)。两组患者主要不良反应为恶心呕吐、腹胀、腹痛、睡眠障碍,分次组恶心呕吐发生率、腹胀发生率低于单次组,两组患者差异有统计学意义(=4.15,4.82;P=0.04,0.02)。结论分次服用PEG能够降低患者的不良反应发生率,提高肠道清洁效果。
Objective To investigate whether the program of graded oral administration of PEG can reduce the adverse reaction of patients with good intestinal cleaning effect. Methods Patients receiving rectoscopebetween June 2015 and December 2015 in our hospital were included. The computer random number generation method was used to divide the patients into graded-dose group（n - 104） and single-dose group （ n = 103 ） . Graded-dose group used divided dose administration of PEG-ES for bowel preparation and single-dose group used single full dose administration of PEG-ES. The endoscopic entering time, Boston bowel preparationscale（ BBPS） scores and adverse reactions in the two groups were compared. Results The average endoscopic entering time of graded-dose group was（ 12. 1 ±4. 6） min and that of single-dose group was（ 11. 9 ± 5. 3 ） min,with no statistically significant difference between the two groups（t= 0. 29 ,P = 0. 77 ） . Graded-dose group BBPS scores averaged（7. 4 ± 2. 2） min and single-dose group BBPS scores averaged（6. 5 ± 1. 9） min. BBPS scores of graded-dose group were superior to single-dose group, with a statistically significant difference（ t= 3. 15 ,P - 0. 00） . Further Ridit analysis showed that the percentage of excellent and good level of graded-dose group was significantly higher than single-dose group,with a statistically significant difference（t =2. 39,P =0. 02 ） . The main adverse reactions of two groups of patients were nausea, vomiting, abdominal distension, abdominal pain, and sleep disorders. Incidence rates of nausea, vomiting and abdominal distension of graded-dose group were lower than single-dose group,with statistically significant differences（t=4. 15,4. 82 ;P =0. 04,0. 02） . Conclusion Graded administration of PEG can reduce the incidence of adverse reactions and improve the intestinal cleaning effect.
出处
《四川医学》
CAS
2016年第8期923-926,共4页
Sichuan Medical Journal
关键词
结肠镜检查
聚乙二醇电解质溶液
肠道清洁
分次服用纳入
colonoscopy
polyethylene glycol electrolytes solution
intestinal cleaning
graded administration
