摘要
目的分析垂体瘤转化基因1(PTTG1)在骨肉瘤组织中的表达,并探讨其表达与骨肉瘤患者预后的关系。方法采用免疫组织化学检测71例骨肉瘤组织和对应的71例正常骨组织中PTTG1蛋白的表达,并分析其表达与骨肉瘤患者临床病理学参数和预后之间的关系。结果 PTTG1蛋白在骨肉瘤组织中的阳性表达率(77.46%,55/71)显著高于正常骨组织(18.31%,13/71),差异有统计学意义(P<0.05)。PTTG1蛋白表达与骨肉瘤患者的肺转移和临床阶段密切相关(P<0.05)。PTTG1高表达的骨肉瘤患者的存活时间明显低于PTTG1低表达的骨肉瘤患者(P<0.05)。结论 PTTG1蛋白在骨肉瘤组织中的表达率显著增高,且与肺转移和生存时间有一定相关性。
Objective To inyestigate the expression of pituitary transforming gene 1 （PTTG1） in osteosarcoma （OS） tissues and explore its association with the prognosis. Methods Expression of PTTG1 protein was detected by immunohistochemistry in 71 cases of OS tissues and 71 cases of paired normal bone tissues, and its associations with clinicopathological features and prognosis were investigated. Results Positive expression ratio of PTTG1 in OS tissues （77.46% ,55/71） was significantly higher than that in normal bone tissues （18.31%, 13/71）, and there was significant difference （P〈0.05）. Expression of PTTG1 protein was tightly associated with lung metastasis and clinical staging ＇of OS patients （P〈0.05）. The survival time of OS patients with high PTTG1 level was significantly lower than those with low PTTG1 level （P〈0.05）. Conclusion Positive expression ratio of PTTG1 protein in OS tissues is elevated significantly,and is associated with lung. metastasis as well as survival time.
出处
《重庆医学》
CAS
北大核心
2016年第24期3366-3368,共3页
Chongqing medicine
基金
河南省高校科技创新人才支持计划(2010HASTIT036)
关键词
垂体瘤转化基因1
骨肉瘤
临床病理学参数
预后
pituitary transforming gene 1
osteosarcoma
clinicopathological features
prognosis
