摘要
目的探讨结肠透析联合尿毒清保留灌肠治疗老年慢性肾脏病(CKD)的临床疗效及安全性。方法选取成都市某医院2010年7月-2015年4月收治的142例老年CKD患者作为研究对象,所有患者均采用结肠透析联合尿毒清颗粒保留灌肠治疗。比较治疗前后患者的血清肌酐(Scr)、尿素氮(BUN)、胱抑素C(CysC)、肾小球滤过率(eGFR)水平的变化情况、临床治疗效果及不良反应发生情况。结果治疗后,患者的Scr,BUN水平低于治疗前,eGFR水平高于治疗前,差异均有统计学意义(P<0.05)。患者的治疗总有效率为56.3%。患者发生不良反应5例(腹泻3例,腹胀1例,肛门疼痛1例),不良反应发生率为3.5%。结论结肠透析联合尿毒清保留灌肠治疗老年CKD效果显著,安全可靠,值得临床推广应用。
Objective To assess the clinical efficacy and safety on the combination treatment of colon dialysis and Niaoduqing granule retention-enema in elderly patients with chronic kidney disease （CKD）. Methods From 2010 July to 2015 April, 142 senile patients with CKD were treated by colon dialysis and Niaoduqing granule retention-enema. Before and after the treatment, serum creatinine （Scr）,blood urea nitrogen （BUN）, Cystatin C （CysC）, estimated glomerular filtration rate （eGFR）, and the clinical efficacy and adverse reaction were observed and statistically analyzed. Results Scr and BUN decreased after treatment with significant differences （P〈0.05）, while eGFR increased （P〈0.05）. The total effective rate was 56.3% Mild adverse reactions occurred in 5 patients （3 cases with diarrhea, 1 case with abdominal distension, 1 case with anal pain） with 3.5% of adverse reaction ratio. Conclusion The combination treatment of colon dialysis and Niaoduqing granule retention-enema in elderly patients with chronic kidney disease is effective, safe and reliable, which is worth being promoted.
出处
《保健医学研究与实践》
2016年第4期34-36,共3页
Health Medicine Research and Practice
关键词
结肠透析
尿毒清
治疗
慢性肾脏病
Colon Dialysis
Niaoduqing Granule
Treatment
Chronic kidney disease
