摘要
目的:通过正交试验与多元非线性回归法,优选注射用炎琥宁的配伍条件。方法:选择放置时间、溶媒种类、溶媒用量和温度4个影响因素,以不溶性微粒数和炎琥宁含量为指标,运用正交试验及多元非线性回归分析法优化配伍条件。结果:注射用炎琥宁最佳配伍条件为在20℃条件下与100 ml的0.9%氯化钠注射配伍,即配即用。结论:正交试验结合多元非线性回归法优选注射剂的配伍条件是一种简便、可行的实验设计方法。
Objective： To optimize the compatibility conditions for potassium sodium dehydroandrographolide succinate for injection by orthogonal test and multivariate nonlinear regression analysis. Methods： An orthogonal test was employed using the number of insoluble particles and the content as the indices and the storage time,solvent,solvent amount and temperature as the influencing factors. Results： The optimum compatibility conditions were as fllows： under the temperature of 20℃,the injection was dissolved in 100 ml sodium chloride injection and used immediately. Conclusion： The combination of orthogonal test and multivariate nonlinear regression analysis is a feasible and convenient method to optimize the compatibility conditions of injections.
出处
《中国药师》
CAS
2016年第8期1581-1583,共3页
China Pharmacist
关键词
注射用炎琥宁
配伍条件
多元非线性回归法
正交试验
Potassium sodium dehydroandrographolide succinate for injection
Compatibility conditions
Multivariate nonlinear regression analysis
Orthogonal test
