摘要
目的:探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者氧气驱动雾化吸入的药学监护点,为临床合理治疗提供参考。方法:240例常规雾化吸入治疗的AECOPD患者随机分成干预组(120例)和对照组(120例)。对照组患者采取常规护理,干预组患者在常规护理基础上进行药学监护,比较两组患者治疗前后的呼吸、心率、血氧饱和度(SPO_2)、疗效、不良反应等。结果:干预组总有效率为91.7%,明显高于对照组的75.0%(P<0.05)。干预组雾化后呼吸频率、心率较雾化前明显降低(P<0.05),且明显低于对照组(P<0.05);SPO_2较前明显升高(P<0.05),且明显高于对照组(P<0.05)。干预组不良反应发生率明显低于对照组(P<0.05)。结论:药学监护可提高雾化吸入治疗AECOPD患者的依从性及耐受性,临床效果更佳。
Objective： To provide reference for the standardized application of oxygen- driven aerosol inhalation in the treatment of acute exacerbation chronic obstructive pulmonary disease（ COPD） at acute exacerbation through investigating the points of pharmaceutical care. Methods： Totally 240 patients diagnosed with COPD at acute exacerbation were randomly divided into the intervention group and the control group with 120 patients in each. The control group was treated with the conventional inhalation,and the intervention group was treated with pharmaceutical care based on the control group. The breathing,heart rate,blood oxygen saturation（ SPO_2）,curative effect and adverse reactions of the two groups before and after the treatment were compared. Results： The efficacy in the intervention group was 91. 7%,while that in the control group was 75. 0%,and the difference was significant（ P 〈0. 05）. After the atomization inhalation,the respiratory rate,heart rate and SPO_2 in the intervention group was（ 18. 0 ± 1. 5）,（ 86. 0 ± 4. 1） and（ 94. 9 ±3. 5）,while that in the control group was（ 20. 0 ± 2. 2）,（ 96. 2 ± 9. 0） and（ 90. 5 ± 5. 9）,respectively. The respiratory rate and heart rate in the intervention group after the atomization inhalation were significantly lower when compared with those in the control group,while SPO_2 was significantly higher than that in the control group（ P 〈0. 05）. The incidence of adverse reactions was significantly lower in the intervention group than that in the control group（ P 〈0. 05）. Conclusion： Pharmaceutical care for COPD at acute exacerbation can significantly improve the compliance and tolerability of patients with inhalation treatment with better efficacy.
出处
《中国药师》
CAS
2016年第8期1507-1509,共3页
China Pharmacist
基金
2013年四川省卫生厅资助课题(编号:130347)
关键词
药学监护
氧气驱动雾化吸入
慢性阻塞性肺疾病
急性加重期
Pharmaceutical care
Oxygen-driven aerosol inhalation
Chronic obstructive pulmonary disease
Acute exacerbation
