摘要
以初黏力、赋形性、综合感官为评价指标,采用Box-Behnken设计对基质处方进行优化,以流变性为评价指标筛选载药量,采用延压法涂布制备,考察物料添加顺序、搅拌速度与时间、干燥温度和时间等工艺参数。优选的基质处方为Viscomate^(TM) NP-700 5.0 g、甘羟铝0.14 g、甘油25 g、EDTA 0.2 g,载药量84 g浸膏。制备的复方独一味凝胶贴膏的外观光滑平整,具有适宜的黏附性,无膜残留,皮肤追随性较好,制备工艺简单、稳定、可行。
Taking the initial adhesion, forming property and comprehensive sense as evaluation indexes to optimize the matrix formulation of Compound Duyiwei Gel Plasters. Using the rheological property as evaluation indexes to screen the drug loading. Calendering processing was used to prepare Compound Duyiwei Gel Plasters, and the process parameters, including the material adding order, stirring speed and time, drying temperature and time, were investigated. The pre- ferred matrix formulation was as follows：ViscomateTM NP-700 5.0 g,Aluminium glycinate 0.14 g,glycerol 25 g,EDTA 0.2 g, and the drug loading was 84 g fluid extract. The compound Duyiwei gel plasters prepared by the optimized pre- scription and preparation technique was smooth ,with appropriate adhesion and without residual behavior, and was feasi- ble for following the skin.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2016年第8期1319-1324,共6页
Natural Product Research and Development
基金
江西中医药大学合作项目(G-057)
