摘要
背景:目前临床上针对颅脑损伤及颅骨缺损等的修复方法及修复材料多样,临床疗效及不良反应也各不相同。目的:对比自体骨、同种异体骨、多孔磷酸三钙和钛网修复颅脑缺损的临床效果。方法:纳入200例颅骨缺损患者,其中男120例,女80例,年龄在18-76岁,采取随机数字表法分为4组,每组50例,分别采用自体骨移植、同种异体骨移植、多孔磷酸三钙、钛网进行修复。对比4组术后并发症情况,随访观察骨性愈合性能。结果与结论:(1)骨性愈合功能:植入后9个月,自体骨移植组、钛网组、同种异体骨移植组骨性愈合性能优于多孔磷酸三钙组(P<0.05),自体骨移植组、钛网组、同种异体骨移植组间骨性愈合性能比较差异无显著性意义;(2)并发症:自体骨移植组、钛网组并发症发生率低于同种异体骨移植组、多孔磷酸三钙组(P<0.05),其余组间两两比较差异均无显著性意义;(3)结果表明:自体骨和钛网修复颅骨缺损具有良好的生物相容性,可促进骨愈合。
BACKGROUND：Currently,different methods materialsused for craniocerebral injury and skul defect repairhave their ownclinical efficacy and adverse reactions.
OBJECTIVE：To compare the clinical effectsof autologous bone, alograft bone, porous tricalcium phosphate and titanium meshforskul defects.
METHODS：200 patients with skul defectswereselected, including 120 males and 80 females, agedfrom 18-76 years old, andthenwere alotted into fourgroups by random number table （n=50 per group）, undergoing repairwith autologous bone, alograft bone, porous tricalcium phosphate and titanium mesh, respectively. The postoperative complications were compared among groups, and osseous healing propertieswere observed throughthefolow-up.
RESULTS AND CONCLUSION：The healing property of autologous bone, alograft bone and titanium mesh was significantly superior tothat ofporous tricalcium phosphate （P〈 0.05）,butthere were no significant differencesamorgthe autologous bone, alograft bone and titanium mesh groups. In addition, the incidence of complications of autologous bone and titanium mesh goup was significantly less than that of porous tricalcium phosphate and alograft bone groups（P〈 0.05）,and comparison betweenthe latter twogroups showed no significant difference. In conclusion, autologous bone andtitanium mesh for skul defectrepair have good biocompatibility, and can promote bone healing.
出处
《中国组织工程研究》
CAS
北大核心
2016年第34期5142-5148,共7页
Chinese Journal of Tissue Engineering Research
