摘要
胶原是人类最主要的结构蛋白,在体内通过自组装形成具有D带的纤维结构,构成人体的各种组织。胶原蛋白具有优异的生物相容性、生物可降解性、无毒性、低免疫性等特点,在材料科学、生物医学、组织工程、生物传感器等领域得到了越来越多的研究和应用。近年来,人们发现,通过合理调控外界环境,胶原蛋白在体外能自组装形成有序的超分子聚集结构,胶原蛋白在体外的自组装行为引起了研究者的广泛关注,逐渐成为研究的热点。本文概括了胶原的自组装机理、外界环境条件对胶原自组装的影响以及胶原自组装基复合材料等方面的工作。
Collagen represents the major structural protein found in the human body, self-assembling into the fiber with a repeating D-periodic gap/overlap spacing, is the main organic building block of many biological tissues in vivo. Collagen has been widely applied and researched in many scientific fields, such as materials science, biomedical, tissue engineering, biosensors and so on, mainly due to its characteristic biodegradability, high biocompatibility, non-toxic, low immunity compared with other biopolymers. In the last few years, collagen was found to self-assemble into the ordered supramolecular structures at appropriate conditions in vitro, which has received great attention of researchers, has been becoming a hot research. This review will focus on the self-assembly mechanism of collagen, the influence of external environmental conditions on the self-assembly of collagen and the self-assembly of collagen-based composite materials.
出处
《高分子通报》
CAS
CSCD
北大核心
2016年第8期18-28,共11页
Polymer Bulletin
基金
国家自然科学基金资助项目(51473150)
河南省教育厅科学技术研究重点项目科技攻关计划项目(13A430705)
关键词
胶原
自组装
超分子结构
Collagen
Self-assemble
Supramolecular structure
